Neuro-Ophthalmology: Neoplastic Chiasmal Disorders Flashcards

0
Q

10 mm

A

pituitary tumor diameter that precedes supradiaphragmatic extension

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1
Q

diaphragma sella

A

structure immediately below the optic chiasm

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2
Q

inferonasal

A

fibers from this region of the retina are thought to contribute to the anterior knee of Wilbrand

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3
Q

superonasal

A

fibers from this region of the retina are most at risk from a pituitary adenoma

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4
Q

prefixed, central, postfixed

A

three chiasmal locations

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5
Q

80%

A

percentage of chiasms that are central

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6
Q

infertility, amenorrhea, galactorrhea

A

triad of symptoms caused by prolactin-secreting adenomas in women

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7
Q

gonadotropins

A

first hormone(s) to be lost in hypopituitarism

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8
Q

GH

A

second hormone(s) to be lost in hypopiuitarism

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9
Q

headache

A

symptom that occurs as a pituitary adenoma impinges on the diaphragma sella but may stop after it breaks through

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10
Q

chromophobe

A

type of adenoma (histologic) that is most likely to cause visual field defects

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11
Q

basophil

A

type of adenoma (histologic) that is least likely to cause visual field defects

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12
Q

dermatochalasis, tilted discs, optic nerve colobomas, nasal retinoschisis, nasal retinitis pigmentosa, functional visual loss

A

six nonchiasmal causes of bitemporal visual loss

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13
Q

color desaturation

A

early sign of chiasmal compression

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14
Q

hypointense

A

pituitary adenoma on T1

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15
Q

hyperintense

A

pituitary adenoma on T2

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16
Q

heterogeneous enhancement

A

pituitary adenoma on T1 with gadolinium contrast

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17
Q

enlargement or erosion of the sella

A

CT findings in pituitary adenoma

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18
Q

prolactin, FSH, LH, GH

A

routine endocrine studies in a patient suspected of having a pituitary adenoma (four)

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19
Q

bromocriptine, cabergoline

A

what two medical interventions for a prolactin-secreting pituitary adenoma may improve visual function in the space of hours?

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20
Q

trans-sphenoidal hypophysectomy

A

usual surgical treatment for pituitary adenoma

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21
Q

1 to 4 months

A

period of most rapid improvement of visual field defects following trans-sphenoidal hypophysectomy

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22
Q

hypopituitarism

A

craniopharyngioma presenting symptom in children

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23
Q

visual field defect

A

craniopharyngioma presenting symptom in adults

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24
Q

isointense

A

appearance of solid components of craniopharyngioma on T1 MRI

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25
Q

hyperintense

A

appearance of cystic components of craniopharyngioma on T1 MRI

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26
Q

radiotherapy

A

adjunctive treatment for pituitary adenomas, craniopharyngiomas, and meningiomas

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27
Q

sphenoidal ridge, olfactory groove, tuberculum sellae

A

three locations for intracranial meningiomas

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28
Q

fullness in the temporal fossa

A

classical finding seen in sphenoidal ridge meningiomas

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29
Q

third ventricle

A

the chiasm forms the anterior border of this structure

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30
Q

tuberculum sellae

A

anterior portion of the sella turcica

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31
Q

dorsum sellae

A

posterior portion of the sella turcica

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32
Q

prefixed

A

term for when the chiasm lies directly over the tuberculum sellae

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33
Q

postfixed

A

term for when the chiasm lies directly over the dorsum sellae

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34
Q

suprasellar cistern

A

term for space in which the chiasm resides

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35
Q

posterior

A

relative location of macular fibers in the chiasm

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36
Q

melanopsin

A

ganglion cells that project to the suprachiasmatic and supraoptic nuclei express this protein (retinohypothalamic tract)

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37
Q

asymmetric

A

characteristic pattern of visual acuity impairment in chiasmal disorders

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38
Q

poor depth perception, diplopia

A

in addition to field abnormalities, patients with chasmal syndromes should be asked about these symptoms

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39
Q

hemifield slide phenomenon

A

cause of diplopia in chiasmal syndromes

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40
Q

sellar sarcoidosis, germinoma

A

two chiasmal disorders for which diabetes insipidus is characteristic

41
Q

30-50

A

70% of pituitary adenomas occur in this age group

42
Q

MEN I

A

multisystem disorder with pituitary adenomas

43
Q

true

A

TRUE or FALSE: diabetes insipidus is an unusual presenting system in pituitary adenoma

44
Q

70%

A

percentage of pituitary macroadenomas which affect vision that are nonfunctional

45
Q

true

A

TRUE or FALSE: visual acuity is not commonly affected by pituitary adenomas

46
Q

hemorrhage

A

T1 hyperintensity in pituitary adenomas usually represents this

47
Q

prognosis

A

importance of OCT in pituitary adenomas

48
Q

visual field loss

A

this parameter has no prognostic significance in visual recovery after pituitary adenoma resection

49
Q

sarcomatous transformation, meningioma

A

secondary tumors caused by external beam radiation of pituitary adenomas

50
Q

within weeks

A

when should a postop visual field be performed following a pituitary adenoma resection

51
Q

false

A

TRUE or FALSE: bromocriptine and octreotide play no role in the treatment of non-prolactinoma pituitary adenomas

52
Q

true

A

TRUE or FALSE: surgery less effective than medical management of prolactinomas

53
Q

ocular hypertension, proptosis

A

ocular effects of gigantism and acromegaly

54
Q

false

A

TRUE or FALSE: thyrotropinomas often result in Grave’s disease

55
Q

corticotropinoma

A

this pituitary adenoma predominates in women of childbearing age and is the least likely to cause visual symptoms

56
Q

gonadotropinoma

A

this pituitary ademona predominates in men over 40 and commonly causes visual symptoms

57
Q

CN III

A

cranial nerve (other than II) most commonly involved in pituitary macroadenomas and pituitary apoplexy

58
Q

headache, vomiting, double vision

A

name the three most common symptoms in pituitary apoplexy

59
Q

false

A

TRUE or FALSE: incidental microadenomas are an indication for ophthalmic exam

60
Q

adamantinomatous, squamous papillary

A

two histological types of craniopharyngioma

61
Q

adamantinomatous

A

adamantinomatous or squamous papillary: craniopharyngioma with “crank-case oil” cysts, calcification, younger age demographic, and tendency for recurrence

62
Q

squamous papillary

A

adamantinomatous or squamous papillary: older age, commonly without cysts, no calcification, uncommonly recur

63
Q

38%

A

incidence of hydrocephalus in craniopharyngioma

64
Q

severe chemical meningitis

A

result of fluid leakage or rupture of craniopharyngioma contents

65
Q

comitant or incomitant esotropia, seesaw nystagmus

A

motility changes in children associated with craniopharyngioma

66
Q

craniopharyngioma

A

pituitary adenoma or craniopharyngioma: diabetes insipidus

67
Q

craniopharyngioma, meningioma

A

CT recommended as an ancillary test to diagnose these entities

68
Q

false

A

TRUE or FALSE: most authorities agree that complete resection of craniopharyngiomas is almost always indicated

69
Q

complete resection

A

bias is towards this craniopharyngioma treatment strategy in children

70
Q

craniopharyngioma

A

pituitary adenoma vs craniopharyngioma: guarded outlook for visual recovery

71
Q

hypopituitarism

A

this tends to get worse after craniopharyngioma treatment

72
Q

Rathke’s cleft cyst

A

ID this tumor: simple cyst lined by cuboidal cells, present in adulthood, calcification rare, good prognosis for vision

73
Q

false

A

TRUE or FALSE: Rathke’s cleft cysts require complete drainage

74
Q

dorsum sellae

A

sellar component rarely involved by meningiomas

75
Q

meningiomas

A

these tumors express progesterone and sometimes estrogen receptors and are known to enlarge during pregnancy

76
Q

frontal

A

typical headache location in meningioma

77
Q

headache, vision loss

A

two most common symptoms of skull-base meningiomas

78
Q

personality changes, anosmia, seizures, hypopituitarism

A

uncommon symptoms/signs of skull-base meningiomas

79
Q

pterional, subfrontal

A

most popular neurosurgical approaches to skull-base meningiomas

80
Q

true

A

TRUE or FALSE: prognosis for visual prognosis after excision of skull-base meningiomas is good

81
Q

tuberculum sellae

A

identify the meningioma location: slowly progressive blindness on one side followed month later by temporal defects in the other eye; best prognosis for vision of skull-base meningiomas

82
Q

anterior clinoid

A

identify the meningioma location: most likely to cause Foster-Kennedy syndrome, commonly involves superior orbital fissure, poor prognosis for vision and high surgical morbidity and mortality given vascular associations

83
Q

diaphragma sella

A

identify the meningioma location: uncommon, often mimic pituitary adenomas, may encase the chiasm

84
Q

true

A

TRUE or FALSE: optic nerve glioma associated with cafe-au-lait spots are sufficient to diagnoses NF1

85
Q

true

A

TRUE or FALSE: optic pathway gliomas in NF1 tend to spare the chiasm

86
Q

yearly neuro-ophthalmic screening exams

A

mandated in all NF1 patients

87
Q

posterior

A

which tends to have higher morbidity and mortality, anterior or posterior chiasmal gliomas

88
Q

apoplectic cystic enlargement

A

cause for sudden vision loss in optic nerve or chiasmal glioma

89
Q

Russell’s diencephalic syndrome, precocious puberty

A

two most common manifestations of hypothalamic involvement in optic chiasm glioma

90
Q

posterior chiasmal

A

only optic pathway gliomas that routinely require biopsy due to inherent uncertainty in diagnosis

91
Q

chemotherapy

A

first-line therapy for optic pathway gliomas that require treatment

92
Q

malignant optic chiasmal glioma

A

this chiasmal tumor commonly mimics unilateral retrobulbar neuritis

93
Q

hypothalamic hamartoma

A

this tumor typically presents with precocious puberty due to release of LHRH but only rarely compresses the chiasm

94
Q

gangliogliomas

A

slow-growing tumors with mixed neuronal and glial elements that tend to arise in the cerebral hemispheres or spinal cord but may compress the chiasm or rarely even arise from the chiasm (they arise from neuronal cell bodies)

95
Q

diabetes insipidus

A

typical presenting symptom of suprasellar germ cell tumors

96
Q

diabetes insipidus, vision loss, hypopiuitarism

A

triad present in the majority of patients with suprasellar germ cell tumors

97
Q

second

A

typical decade in which suprasellar germ cell tumors present

98
Q

histologic subtype

A

main determinant of survival in suprasellar germ cell tumors

99
Q

subcutaneous fat

A

appearance of epidermoids and dermoids mimics that of this on MRI