Neuropathology II Flashcards Preview

MBB Block II > Neuropathology II > Flashcards

Flashcards in Neuropathology II Deck (18):
1

What are the perikaryon changes/reactions?

eosinophilia, atrophy, chromatolysis, storage, inclusions, lipofusin, neuronophagia, cell loss

2

What are axonal reactions?

wallarian degeneration, dying back degeneration, demyelination, spongy degeneration of myelin, spheroids

3

What are the neuronal reactions seen in neutropil?

neuritic plaques, spheroids, status spongiosis
(spheroids of infantile neuroaxonal dystrophy)

4

What are the two kinds of astrocytes?

protoplasmic of the gray matter and fibrous of the white matter and periventricular areas

5

What is astrocytosis?

hypertrophy of astrocytes. may be protoplasmic or metabolic

6

What is gliosis?

astrocytic proliferations

7

What may I see in astrocytes in the patients with hyperammonemia?

protoplasmic astrocyte responce of enlargement and nuclear lobulation

8

What are Alzheimer type II glia?

astrocytic nuclei with distinct lobulations and eosinophilic granules. bigger.

9

What inclusions occur in astrocytes?

corpora amylacea and Rosenthal fibers. corpora amylacea common in the aging brain (near pia, ependyma, perivascular areas). Rosenthal fiber eosinophilic, elongated irregular accuulations.

10

When do you see Rosenthal fibers?

Rosenthal fibers are the hallmark of low grade tumors, as seen in juvenile pilocytic, astrocytoma, and Alexander's disease

11

What are the oligodendroglial reactions?

hyperplasia, cell loss, storage, inclusions, neoplasia. Focus on neoplasm and necrosis.

12

What is the regenerative capacity of oligos in comparison with other cells?

more than neurons, less than astrocytes or Swhann cells

13

What are the ependymal reactions? I

cell loss and neoplasia (thought normal cells have only limited regenerative capacity)

14

What are the microglial reactions?

hypertrophy, hyperplasia.

15

When do you see multinucleated giant cells?

HIV subacute encephalitis

16

What are the reactions of endothelium?

hypertrophy, hyperplasia, fibrosis, cell loss, neoplasia

17

What cells have good regenerative potential, and what cells have limited regenerative potential

good: astrocytes, microglia, endotheliuma
limited: ependymal, oligos

18

What are the meningeal reactions?

fibrosis, metaplasia, hyperplasia, neoplasia. Neoplasia is the predominant lesion