Neuropharm V Flashcards Preview

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Flashcards in Neuropharm V Deck (17):
1

What should I know about amphetamines actions, esp. in comparison?

Methamphetamine has more CNS effects than amphetamine
methylphenidate is a weaker cNS agent but has more effect on mental activity.

2

MOA of amphetamines.

block reuptake of catechols and enhance release from terminals. can lead to depletion.

3

What are adverse effects of amphetamines?

headache, dizziness, agitation, dysphoria, delirium, psychosis, palpitations, dependence, tolerance and addiction with severe withdrawal

4

How can amphetamines be used therapeutically?

treat depression, dementia where abulia is prominent
treats ADHD (both methylphenidate and amphetamine)
may be good for narcolepsy
used to be used for diet/appetite suppression, but no more due to sides

5

MOA of LSD?

agonist at 5HT receptors

6

Whad does LSD do?

euphoriam illusions/hallucinations, synesthesia, labile mood. Also sympathetic activation. cross-tolerance may occur.

7

What are adverse effects of LSD?

flashbacks, anic attacks, depression, paranoia, psychotic episodes

8

What is PCP? Related compounds and former uses?

hallucinogen related to ketamine that was used as an anesthetic but caused too much delirium

9

MOA of PCP

inhibits re-uptake of amines and 5HT; anticholinergic activity, NMDA blocker

10

What are some negative side effects of PCP

intoxication, staggering gait, numbness, sweating, regidity, severe violent agitation not responsive to human interaction.
may cause stupor, coma, increase HR, BP, fever, delirium, convulsions (toxic doses)
chronic use: personality changes, anxiety, depression, psychosis

11

What are the 5 targets of GABA use again?

synthesis, release, receptors, reuptake, metabolism

12

What are GABA-A receptors?q

ligand gated chlorine channels.

13

What is muscimol?

GABA channel agonist.

14

What should I know about GABA subunits?

alpha and beta have GABA binding sites. also change affinity for GABA and alter BDZ specificity
gamma required for BDZ sensitivity

15

What are examples of agonists to the BDZ receptor? Inverse agonists?

diazepam. augment GABA responses by increasing the affinity for GABA
inverse agonist is Beta carbolines: these reduce GABA responses and produce anxiety and convulsions.

16

What are BDZ site antagonists?

no intrinsic activity at the receptor but they do block the action of agonists and inverse agonists. Ex: Flumanezil

17

Example of drugs at the barbiturate site. MOA.

related to phenobarbital.
increase GABA response by increasing duration of channel opening. more sedative.