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Flashcards in neuropharm basics Deck (18):
1

excess glutamate can lead to?

excitotoxicity (ALS, AD, neuropathic pain)

2

glutamate ionotropic or metabotropic?

both

3

glutamate secreted by

pyramidal cells

4

three important types of ionotropic glutamate receptors

- NMDA
- AMPA
- Kainate

5

name two NMDA receptor antagonists

- PCP
- ketamine

6

explain the regulation of the NMDA receptor

- needs glycine as a co-agonist
- modulated by Zn and polyamines
- blocked by Mg at RMP
- Ca permeability, acts as messenger

7

explain metabotropic glutamate receptors

- groups I-III
- act through G protein coupled receptors
- regulate Ca or adenyl cyclase in cell

8

GABA synthesis

from glutamate by GAD

9

important drugs that work through GABA receptors

- benzos
- barbiturates
- alcohol
- general anesthetics

10

important features of GABA-a receptors

- ionotropic
- a-subunit opens Cl channel
- hyperpolarization

11

features of GABA-b receptors

- metabotropic (G protein coupled channel)
- opens K
- closes Ca
- efflux of K causes hyper polarization

12

features of GABA-c receptors

- ionotropic
- only one type of subunit
- opens Cl channels
- expression in retinal, spinal cord, pituitary
- not modulated by benzos etc.

13

major subcategories of monoamines

- serotonin
- catecholamines
- histamine
- tryptamines (5-HT and melatonin)

14

dopamine (DA) where made and what involved in?

- ventral tegmental area and substantial nigra
- behavior, cognition, movement, motivation, reward, addiction

15

dopamine receptors types

D1 and D5 - increase adenylyl cyclase - excitatory
D2-4 - increase phosphodiesterase - inhibitory

16

what's the difference between metabotropic and ionotropic receptors?

- ionotropic - opening of ion channel
- metabotropic - secondary messengers, metabolic pathways, g-proteins

17

inhibitory and excitatory amino acid NTs

excitatory - glutamate, aspartate
inhibitory - GABA, glycine

18

nicotinic vs muscarinic receptors

nicotinic - ionotropic
muscarinic - metabotropic

both ACh receptors