Flashcards in Quiz 3 - disorders of neuromuscular system Deck (68)
myelin in the peripheral nerves comes from.....
myelin quantity and function
heavy - somatic motor, sensory to reflexes
intermediate - touch, proprioception, joint position
light - sharp pain, autonomic motor preganglionic
none - burning, aching, temp, postganglionic autonomic
more sensory loss in peripheral or nerve root damage?
peripheral, in nerve root damage there is overlap
fasciculations, along with weakness and/or atrophy indicates damage to what?
anterior horn cell or its axons
what does weakness with a high firing rate of motor units indicate?
compensation for loss of motor neurons or axons
what are the two pediatric inherited anterior horn cell degenerative diseases and who do they affect?
Werdnig-Hoffman - infants
Kugelberg-Welander - children/young adults
ALS damage is usually to what?
both upper and lower motor neurons
who usually gets ALS
weakness in ALS
can be varied between upper and lower motor neurons in single patient
CN involvement in ALS
- tonge, face, phalanx, soft palate
- NOT eyes
longevity and death in ALS
- 3-5 years
- due to respiratory muscle weakness and superimposed infection
ALS involving only upper motor neurons is called
primary lateral sclerosis
ALS involving only lower motor neurons is called
progressive muscular atrophy
ALS involving only cranial musculature is called
progressive bulbar palsy
what drug slows down ALS?
3 categories of peripheral nerve damage
2) mononeuropathy multiplex
mononeuropathy is most often due to
PE technique for mononeuropathy
Tinel sign, tapping at place of damage for mechanical sensitivity
most common mononeuropathy
carpal tunnel syndrome
damage to the radial nerve is indicated by
nerve damage in thoracic outlet syndrome is in the distribution of the....
what is radiculopathy?
damage to nerve root
causes of radiculopathy in younger and older adults
younger - disc herniation
older - degenerative issues in discs, bones, joints
- usually symmetrical
why are legs affected first in polyneuropathy?
- longer nerves with higher energy demand
indication of larger fiber polyneuropathy
- loss of vibration and joint position sense
- can result in poor balance
most common symptoms of polyneuropathy
- dysesthesias, paresthesias
most common causes of polyneuropathy
heavy metal exposure
chemo and antivirals
diseases that can cause polyneuropathy