Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year 2 Respiratory > Non-infectious inflammatory diseases of the lung > Flashcards

Non-infectious inflammatory diseases of the lung Flashcards

1
Q

sarcoidosis

A

multisystem granulomatous inflammatory disease of unknown etiology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the risk factors for sarcoidosis (ethnicities, exposures)?

A

african americans
danes
swedes
exposure to insecticides, ag employment, microbial aerosols

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the general manifestations / clinical presentation of sarcoidosis?

A

involvement of lymphatic and pulmonary system

dry cough, SOB

like TB without the infectious part

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is seen on PE with sarcoidosis?

A 
adenopathy 
skin lesions (lupus pernio, erythema nodosum)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is seen on labs in sarcoidosis?

A

calcium levels
liver enzymes
creatinine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what ancillary tests should be performed for sarcoidosis?

A

ECG (for heart block)
opthalmologic
TB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is seen on PFTs in sarcoidosis?

A

restrictive

decreased TLC
decreased VC
decreased RV
decreased DLCO

usually interstitial - limits expansion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the diagnostic procedure for sarcoidosis? what does it check for?

A

bronchoscopy to check for

BAL - lymphocyte, granulocyte count
CD4/CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

when are systemic corticosteroids indicated for sarcoidosis?

A 
cardiac involvement 
ocular disease 
neuro disease 
hypercalcemia 
lupus pernio 
symptomatic stage II 
stage III
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the CT diseases that affect the lung?

A 
RA 
scleroderma 
SLE 
sjogren 
dermatomyositic and polymyositis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the demographics and clinical features of RA that affects the lung?

A

male > female 50-60 yo

ILD 50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is the presentation for rheumatoid lung disease?

A

non productive cough
dyspnea on exertion
may precede joint disease by years
clubbing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the auscultatory findings of rheumatoid lung disease?

A

inspiratory fine crackles

pleural rub

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the radiographic findings of rheumatoid lung disease?

A

nodules that can cavitate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what are the medications for rheumatoid lung disease?

A

methotrexate
etanercept
infliximab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what lab result is indicative of rheumatoid lung disease? why?

A

low glucose

bacteria are consuming the glucose

17
Q

what are the two types of diffuse scleroderma lung disease?

A

interstitial lung disease

limited (CREST)

18
Q

what is indicative of interstitial lung disease form of scleroderma on auscultation? what type of lung physiology is represented?

A

inspiratory crackles

restrictive lung physiology

19
Q

what is seen in the limited (CREST) form of scleroderma?

A

pulmonary HTN

decreased DLCO

20
Q

what is the most common presentation of SLE pulmonary involvement? what are other findings?

A

serositis

alveolar hemorrhage
diaphragmatic dysfunction
increased risk for DVT/PE** (hypercoagulable state)

21
Q

what constitutes sjogren syndrome lung involvement?

A

airway compromise

bronchiestasis and bronchiolitis

22
Q

what is a common manifestation of polymyositis / dermatomyositis pulmonary involvement?

A

aspiration pneumonia secondary to pharyngeal muscle weakness

23
Q

what are the PFT findings for polymyositis / dermatomyositis?

A

restrictive

24
Q

wegener’s granulomatosis

what structures are involved?

A

necrotizing granulomatous vasculitis of small and medium vessels

upper and lower respiratory tract and kidneys

25
Q

what are the symptoms / presentations of wegener’s granulomatosis?

A

sinus symptoms
cough
hemoptosis
constitutional symptoms

26
Q

which antibody is specific to wegener’s syndrome?

A

cANCA

27
Q

what is the diagnosis for goodpasture’s syndrome?

A

presence of anti-glomerular base membrane antibodies

28
Q

what is seen on bronchoscopy for goodpasture’s syndrome?

A

persistent bloody fluid that does not clear on serial samples

29
Q

how can diffuse alveolar hemorrhage present?

A

as the initial manifestation of a pulmonary vasculitis

30
Q

what is the triad of churg-strauss syndrome?

A

asthma
hypereosinophilia
necrotizing vasculitis

31
Q

what are the two phases of churg-strauss syndrome?

A

prodrome

eosinophilic

32
Q

what is are the organ involvements in churg-strauss syndrome?

A

reversible airflow limitation
CV complications
GI - can be severe

33
Q

what is seen on lab findings for churg-strauss syndrome?

A

eosinophilia (diagnostic)
elevated IgE
positive pANCA

Year 2 Respiratory (34 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions