Non-Invasive Carcinoma's Flashcards
(21 cards)
Non-invasive breast cancer
Epithelial proliferation that is still confined to the terminal duct lobular unit (TDLU)
- localized within a duct
What is the difference between non-invasive and invasive breast cancer?
Non-invasive tumours have not invaded beyond the basement membrane and is incapable of metastasis
- invasive cancers do
What is the most common non-invasive breast cancer?
Intraductal carcinoma
- DCIS (ductal carcinoma in situ)
What % of DCIS make up breast cancer?
20%
Is DCIS palpable or symptomatic?
No
How is DCIS with the ducts / surrounding tissue?
Completely contained within the ducts and has not spread into the surrounding breast tissue
What does DCIS commonly have on mammo?
Microcalcifications
- 70-90%
How many different grades of DCIS are there?
3
- low (low risk)
- intermediate
- high (aggressive)
How is DCIS typically treated?
Surgically by removal of the mass
- the higher the grade the more breast tissue that needs to be removed
What are common followings after surgically removing DCIS? (2)
- Radiation
- Medication
- eg. tamxoiphen
What % of low grade DCIS can progress into invasive carcinoma if left untreated?
53%
LCIS
Lobular carcinoma in situ
DCIS
Ductal carcinoma in situ
- Intraductal carcinoma
Is LCIS a treu cancer?
No
What is the difference of LCIS compared to DCIS?
Non-invasive process without a specific mass effect
Where are the atypical cells found with LCIS?
Lobules
- not the ducts
What is LCIS considered?
A marker for increased risk of breast carcinoma
What kind of Pt is LCIS more commonly found in?
Premenopausal women
Is LCIS more commonly unilateral of bilateral?
Bilateral
How is LCIS found?
With Bx only
- not seen on mammo or US
