(P4) Resp Patho: Sarcoidosis of the lung

Question 1

Identify:

Answer 1

Sarcoidosis of the lung

1. Necrosis around granuloma
2. lymphocytes
   * *3. giant cells***
   * *4. epithelioid cells***
3. BTNL gene
4. lymph nodes, spleen, liver, bone barrow, skin, salivary glands, muscle

Question 2

Identify:

What are the causes of this lesion?

Answer 2

Sarcoidosis of the lung

• Worldwide disease affecting all races and sexes
• Causes are multifactorial – environmental and genetic (BTNL gene)

Question 3

This lesion can also affect what other organs?

Answer 3

Sarcoidosis of the lung

Lung, lymph nodes, spleen, liver, skin, uveal tract, bone marrow

Question 4

This lesion is considered to be what type of inflammation?

Answer 4

Granulomatous inflammation

NO caseous necrosis

Question 5

IN

Sarcoidosis of the lung

what is scattered in the interstitium of the lung?

Answer 5

Multiple, sarcoid granulomas are scattered in the interstitium of the lung

Question 6

Identify this lesion:

What type of cells are present?

Answer 6

Sarcoidosis of the lung

Granuloma - lymphocytes, giant cells, epithelioid cells (macrophages)

Asteroid bodies (star-shaped crystals) may be seen inside giant cell

Schaumann bodies (small calcifications with a laminar structure) may be present inside Langhans cells

Question 7

Slide:

Micro presentation:

Answer 7

Lymphocytes on the edges, central part with epithelioid cells (not just on the edge like regular granuloma).

Giant cells, Many granulomas

Question 8

IDENTIFY:

Answer 8

Question 9

Identify:

Answer 9

Sarcoidosis of the lung