PANCE Hematology 8/10/20 Flashcards
(115 cards)
1
Q
what are the 2 components of RBC
A
heme (fe)
globin
2
Q
how is iron stored
A
ferritin
3
Q
what is the feritin level with Fe deficiency anemia
A
decreased
4
Q
what is the feritin level with anemia of chronic disease
A
increased
5
Q
what are the two types of anemia
A
intrinsic (inherited)
extrinsic ( acquired)
6
Q
what anemia: HgbS
A
- sickle cell
7
Q
what anemia: episidic anemia associated with sulfa drugs fava beans and infections
A
G6PD deficiency
8
Q
what is coobs +
A
autoimmune hemolytic anemia
9
Q
what is the pentad with TTP
A
hemolytic anemia thrombocytopenia kidney damage neurologic fever
10
Q
HUS triad
A
- thrombocytopenia
- hemolytic anemia
- kidney damage
11
Q
popcorn: rouleaux formation
A
multiple myeoloma
12
Q
Popcorn: Howell Jolly bodies
A
sickle cell
13
Q
popcorn anemia:
- target cells 2
A
sickle cell
thalassemia
14
Q
popcorn anemia:
- spherocytes
A
heriditary spherocytosis
15
Q
popcorn anemia
- hypersegmented neutrophils 2
A
B12
folate
16
Q
popcorn Blood:
auer rods
A
AML
17
Q
popcorn Blood:
reed sternberg
A
hodgkins lymphoma
18
Q
what three things can cause anemia
A
- RBC loss
- RBC destruction
- Dec RBC production
19
Q
what if there is anemia with decreased reticulocyte counts
A
that means the Bone marrow is not working well
20
Q
what are the three microcytic anemia
A
- Fe deficincy
- lead
- thalassemia
21
Q
what is the primary cause of normocytic anemia
A
anemia of chronic disease
22
Q
what are the two macrocytic anemia
A
B12
Folate
23
Q
what has neuro factors B 12 or folate
A
B 12
24
Q
what do you have to look for when giving B12
A
hypokalemia
25
what is the + shillings test dx
- pernicious anemia
26
ETOH causes what type of anemia
macrocytic
27
ringed sideroblast and basophilic stippling what anemia
Lead poisoning
28
what type of hemoblibin in a baby
F
29
Popcorn anemia: hair on end appearance X ray
Beta thalasemia
30
what is the mC cause of G6pD crisis
infections
31
what are the 2 tx for sickle cell crisis
1. fluids
| 2. hydroxyuria
32
how do you tx autoimmune hemolytic anemia
- steroids
33
what is the MCC of autoimmune hemolytic anemia
SLE
34
adsams 13 is associated with what pathology
TTP
35
HUS is assocated with what infection
- e coli
| - or another gastritis such as shigella
36
how do you treat TTP 2
plasmapharesis
| steroids
37
do you give HUS abx
no it will make them worse
38
what type of condition is TTP
autoimmune
39
How do you treat TTP and HUS
plasma phoresis
40
what causes DIC 3
- gram - infections
- malignancies
- obstetric
41
how do you treat DIC
FFP
42
what causes the increased bleeding with ITP
idiopathic
43
isolated thrombocytopenia w/o splenomegaly
Idiopathic thrombocytopenia
44
what do kids have prior to ITP
viral infection
45
How is hemopehila A and B transfered
X linked recessive
46
what bleeding pathology can be treated with desmopressin (2)
hemophilla 8
| WVD
47
what is the gold standard test for VWD
ristocetin
48
what virus infection is associated with hogkins lymphma
- EBV
49
what is the clinical presentation for hogkins lymphoma
painless lympadenopathy
| turns painful with ETOH
50
"owl eye"
hogkins lymphoma
51
what lymph nodes for hogkins lymphoma
cervical and supraclavicular
52
what may you see on a chest CT with hogkins lymphoma
mediastinal lymphadenopathy
53
what lymph nodes for non hodgkins lymphoma
peripherial
54
Birket lymphoma is associated with what type of lymphoma
non hodgkins
55
"stary night on blood smere"
Birket lymphoma
56
How do you tx multiple myoloma
stem cell transplant
57
"M spike"
| "bence jones protein"
multiple myoloma
58
what is the most common leukemia in adults
CLL
59
what are the three myeloid cells
- RBC
- WBC
- platelets
60
what condition is an increase in all three myeloid cells
polycythemia vera
61
puritis after a hot bath
PV
62
how do you tx PV
- phlebotomy
| - hydroxyurea
63
increased hematocrit as a response to another process (COPD)
secondary erythrocytosis
64
what are the three conditions that may cause you to clot more
- factor V leiden mutation
- protein C deficiency
- antithrombin III dificiency
65
- blueberry muffin rash
- hepato spleno megaly
- hearing loss
- mental retardation
toxoplasmosis
66
what CD4 count for toxoplasmosis
100
67
what is the tx for toxoplasmosis
sulfadiazadine + pyrimetherine
68
MRI: ring enchnacing lesions
toxoplasmosis
69
how do you tx enterobiasis (pin worm)
- albendazole
70
bite cells 2
- thalasemia
| - g6PD
71
autoimmune distruction of the pariietal cells
PA
72
Inc Homocystine
AND
Inc methocyctine
what anemia
B 12
73
B9 what Vit
folate
74
what thyroid disorder causes macrocytic anemia
hypothyroid
75
pagopahgia is what
ice craving
76
pagopahgia is what pathology
iron deficiency anemia
77
what Vit Increases iron absorption
vit C
78
anemia ?
abdominal pain
constipation
neurological symptoms
lead poisoning
79
tx for thalasemia
blood transfusions
80
what group is belta thal more common in 2
- mediterranian
| - Africans
81
HEINZE BODIES 2
beta thalasmemia
| G6PD
82
what is the feritin with anemia of chronic disease
increased
83
what type of disease is sickle cell
autosomal dominate
autosomal recessive
autosomal recessive
84
aplastic crisis with sickle cell what virus
parvo B 19
85
what population gets priapism
sickle cell
86
coombs test differentiates how
autoimmune hemolytic anemia
| hereditary spheroscytosis
87
deep tissue bleeding
hemophilia B
88
hemophilia B tx
factor 9 infusion
89
"hemearthrosis"
hemophilia A
90
bleeding after minor lacerations
von willebrabnd
91
proonged PTT that corrects with mixing study
hemophilia B
92
what medication do you wnat to avoid with VWB
aspirin
93
what group gets alpha thal
asian
94
how do you tx hereditary spherocytosis
splenectomy
95
osmostic fraginity test
hereditary spherocytosis
96
dark urine at night of first thing in the AM
nocturnal hemoglobinuria
97
nocturnal hemoglobinuria test
flow cytometry
98
what are the coas with TTP
normal
99
what is increased with HUS
BUN/ CR
100
how do you tx ITP in adults
steroids
101
does ITP have splenomegaly
no
102
what pathyway for hemopheilla 8
intrinsic
103
what is prolonged with hemopheilla 8
PTT
104
what pathology is PT and PTT prolonged
DIC
105
how to tx waldenstrom macroglobulinemia 2
- chemo
| - plasmapheresis
106
what pathology is a risk for ALL
downs
107
what is the mC symptom of ALL
FEVER
108
ALL TX
chemo
109
smudge cells
CLL
110
MC symptom of CLL
fatigue
111
what is associated with teh jack 2
PV
112
Bronze skin
hereditary hemachromatosis
113
hereditary hemachromatosis dx
liver biopsy (hemosiderin)
114
hereditary hemachromatosis tx
phelobotomy
115
recurrent DVT and PE think what
hypercoag disorder
