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Flashcards in Pancreatic Diseases Deck (38)
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1

Case: A 46yo man with a h/o gallstones presents to the ER with a 1 day history of severe epigastric pain which radiates to his mid-upper back
Patient reports nausea and vomited en route to the hospital
He is diaphoretic and believes he has a fever but has not taken his temp.
**Epigastric pain, mid-upper back**
History of GRED, ulcers, taking PPIs, peritoneal signs....

Acute Pancreatitis

2

Most cases of acute pancreatitis are related to

the biliary tract (often a passed gallstone) or heavy alcohol intake

-Generally there is some insult to the ampulla of Vater causing obstruction and reflux of bile into the pancreatic ducts causing damage and inflammation to the cells of the pancreas

3

_______ itself can cause pancreatitis

ERCP procedure

4

Acute pancreatitis may also be caused by

Medications, viruses, autoimmune, high cholesterol also are considerations

5

GET SMASHED
(thinks that cause pancreatitis)

Gallstones
Ethanol
Trauma
Steroids
Mumps
Autoimmune
Scorpion venom
Hypothermia/Hyperlipidemia
ERCP
Drugs- azathioprine, thiazines, sodium valproate, tetracycline

6

Big blues to think acute pancreatitis

History of gallstones or heavy drinking
Trauma directly to pancreas (insult to gut, kid going over handlebars)

7

Signs and symptoms of acute pancreatitis

-Most patients have epigastric abdominal pain (often abrupt onset, radiates to the back, worse when laying flat; better when laying in the fetal position or leaning forward)
**Nausea and vomiting are usually present**
-Possible history of a heavy meal or heavy alcohol consumption prior to the attack
-Abdomen is generally tender on exam
-Fever is often present
-Mild jaundice may be seen

8

Pancreatitis may also be caused by obstruction of

ampula of vader from stone, etc.

9

Lab findings for pancreatitis

**LIPASE is most specific and stays high for longer**
-Elevations in amylase and lipase
-Generally 3x the upper limits of normal within 24 hours of symptoms
-Return to normal is variable
-Elevated WBC count- not always infection, can be inflammation
-Hyperglycemia (pancreas isn’t functioning properly- isn’t producing insulin properly)
-Hyperbilirubinemia and/or elevated LFTs may be present as well
-High creat is associated with progression to pancreatic necrosis

10

Severity of pancreatitis depends on

Presence of a systemic inflammatory response syndrome (SIRS) or sepsis can independently be associated with a greater mortality rate

11

_______ is widely used to determine the severity of acute alcoholic pancreatitis
Sensitivity of predicting a severe course as accurate as 60-80% based on these criteria

Ranson’s criteria

12

Ranson's Criteria

At admission or diagnosis:
-Age over 55
-WBC count over 16,000
-Blood glucose over 200
-Serum lactic dehydrogenase (LDH) over 350
-Serum AST over 250

During initial 48 hrs
-Hematocrit fall greater 10% points
-Blood urea nitrogen rise over 5 mg/dl
-Arterial PO2 below 60mmHg
-Serum calcium below 8 mg/dl
-Base deficit > 4
-Estimated fluid sequestration over 6000 ml

*more you have=higher risk of mortality

13

"Sentinel Loop" and "Colon cutoff Sign" seen in xray

-“sentinel loop” is a segment of air-filled small intestine usually in the LUQ (Air filled small bowel; air filled loops towards stomach- google image)


-“Colon cutoff sign” is a gas-filled segment of transverse colon abruptly ending at the area of pancreatic inflammation
(cutoff right where pancreas is, showing potential acute inflam- google image)
-Plain radiographs may show calcified gallstones

14

Ultrasound helpful?

Ultrasound can be helpful for identifying gallstones/cholecystitis but generally not helpful for pancreatitis given overlying bowel gas

15

CT helpful?

-CT can help to identify and enlarged or inflamed pancreas
-Can also show necrosis, pseudocyst, or other complications

16

Physical signs that present in 1-2% of pancreatitis cases

Cullen sign (bruising around umbilicus)
Grey Turner's sign (bruising along side, flank)

-usually present together, correlate high with pancreatic necrosis

17

Treatment for mild pancreatitis

-Most cases are mild and will subside over a few days
-Bowel rest, bed rest, pain control
-Fluid resuscitation
-Classically meperidine has been given for pain preferentially over morphine due to risk of--> Morphine may cause spasm of sphincter of odi (now people don’t think this but may still be test answer- older way of thinking)
Now thought to be an acceptable alternative and is often preferred
-Slowly resume p.o. diet when pain free, bowel sounds are present, and labs are improving
-Even eating a little food/drinking/hard candy will cause pancreas to think your eating and it will start contracting causing severe pain
-Must do FULL gut rest

18

Treatment for severe pancreatitis

-Large amounts of IVF resuscitation due to volume loss in necrotizing disease
-Treatment of sepsis and evolving multi-organ dysfunction
-Calcium replacement if hypocalcemic
-Enteral feeding via nasojejunostomy preferred
-Parenteral nutrition (TPN) in those with ileus

19

Drug of choice for necrotizing pancreatitis

Carbapenems (imipenem) considered the drug of choice for necrotizing pancreatitis involving >30% of the pancreas (more than 1/3)
-Antifungals a consideration as well, if sick for longer, higher blood glucose (pancreas isn’t working), want to prevent yeast/candida

20

Complications of acute pancreatitis

1. Intravascular volume depletion due to leakage of fluids in the pancreatic bed and ileus can cause acute renal insufficiency/ATN (could last 1-2 weeks and in some cases patients require hemodialysis)

2. Pancreatic necrosis and fluid collections (pseudocysts) can be acute or chronic and can be sterile or infected
-This complication occurs in 5-10% of cases and is a frequent predictor of mortality
-An infected pseudocyst can form a pancreatic abscess; often associated with splenic vein thrombosis and L sided pleural effusions as well

3. Fistula formation, erosion into a blood vessel, chronic pancreatic insufficiency and permanent diabetes may also occur

21

______ should follow all severe cases especially with nercocosis/pseudocyst

Surgery

-Some mild cases with stones may need a cholecystectomy or cholecystotomy

22

________ may improve survival but patient must be good candidates

Necrosectomy

-If possible delay until patient is stable and necrosis has organized

23

Internal or external drainage of pseudocysts a consideration as well, but risk for _________

infection and fistula formation

-Mortality rates in the most severe cases are 25% and if there is multiorgan failure present, 50%

24

Case: A 65yo man with a h/o chronic alcohol use presents to the ER with a c/o intermittent epigastric pain, weight loss, and diarrhea. Frequent, watery diarrhea, green-yellow color, prefers to drink liquids, not much solid food; no recent travel. "Oily stools" seen and CT scan demonstrated diffuse pancreatic calcifications (chronic irritation) and some ductal dilation.

Think chronic pancreatitis

**Think alcoholics (smoking accelerates process)

25

Labs with chronic pancreatitis will show

-mild elevation in amylase and lipase
-Serum alkaline phosphatase and bilirubin are slightly elevated

26

Chronic pancreatitis is characterized by

1. persistent or intermittent epigastric pain
2. steatorrhea
3. weight loss
4. up to 30% of affected patients have calcifications of their pancreas on CT
5. Nearly 80% of cases due to chronic alcoholism

27

Mnemonic for predisposing factors to chronic pancreatitis

T – toxic metabolic
I – idiopathic (10-30% of cases)
G – genetic
A – autoimmune
R – recurrent and severe acute pancreatitis
O - obstructive

28

Another preexisting disease that can cause chronic pancreatitis is

Hyperparathyroidism- which increases levels of serum calcium can lead to increased calcium deposition in the pancreas and be a cause

29

Hallmarks of autoimmune pancreatitis

Elevated levels of IgG and certain autoantibodies

30

80% of adults develop _____ within 25 years after the onset of chronic pancreatitis

diabetes