Abortion definition
deliberate termination of human pregnancy, normally first 28 weeks
Perinatal period
From 16 weeks to 28 days after birth
Risks for perinatal death not caused by congenital anomalies (7)
Dizygotic (fraternal) twins
Originate from 2 zygotes, account for about 2/3 of twins, rates increase with age, can be same or different sex, and having one set increases likelihood of having it happen again
Thick seputm and 2 zygotes on ultrasound indicates…
….dizygotic twins
Dizygotic twins have __ amnion and chorions, the monozygotic varies based on when the zygotes divide during development
2
Monozygotic (identical) twins, when do they become conjoined?
one fertilized ovum, cleavage before 72 hours results in dichorionic diamniotic (best outcome) twins, between days 4-8 monochorionic diamnionic (2nd best) twins, and if 8-13 monochorionic and monoamnionic (worst) twins. Cleavage after day 13 will result in conjoined twins***
Twin complications
Prevention of preterm labor (3)
Any 12+ (adult) who has even 2 recurrent seizures unprovoked by proximate insult is considered ___, in children they can be due to ___ as well
epilepsy, fevers
Epilepsy and pregnancy
90% of women have a normal pregnancy, not a contraindication, however increased risk for perinatal complications
Sudden unexpected death in epilepsy (SUPEP)
Sudden unexpected witnessed or unwitnessed non traumatic or non drowning death with or without evidence for seizure excluding status epilepticus which does not have autopsy reveal structural or toxicologic cause of death
__% of all pregnancies are unplanned
50%
Antiepileptic drug lower ___ putting developing infant at increased risk for ___
folic acid, neuro tube defects
All pregnant women should be on __ mg folic acid, epileptics should be on ___
.4-.8, 4mg
Valproate and pregnancy
Antiepileptic contraindicated in pregnancy because of high teratogenicity unless already established pregnancy (don’t want to have seizure occur during change over)
Drug of choice for seizure abortion in delivery
Lorazepam
Fetal hydantoin syndrome
Caused by phenytoin (antiepileptic )use in pregnancy can result in craniofacial anomalies, IUGR, developmental delay, cleft lip/palate, etc
Spinal bifida
a birth defect that occurs when the spine and spinal cord don’t form properly. It’s a type of neural tube defect. The neural tube is the structure in a developing embryo that eventually becomes the baby’s brain, spinal cord and the tissues that enclose them, treated thru surgery
Keppra (levetiracetam) while pregnant
Antiepileptic drug that is the safest for women of reproductive age as it has the lowest incidence of birth defects (same as unexposed pregnancies)
Anticoagulants in pregnancy
Heparins are the safest choice, lovonox (lmw heparin) is used throughout with switch to unfractionated heparin in the last month of pregnancy since it is more quickly reversed, anticoagulated patients are not eligible for epidural analgesia,does not cross the placenta so no worry about harming the fetus
Pregnancy coagulability
Pregnancy is a hypercoaguable state with increased factor II, VII, VIII, X, and XII and decreased protein S
Most DVT occur in the __ leg in pregnancy
left
5 inherited autosomal thrombophilias
-factor v leidan
-prothrombin gene mutation
-hyperhomocystinemia
-protein C deficiency
Protein S deficiency