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Maddy - First Aid > Path > Flashcards

Path Flashcards

(85 cards)

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1
Q

ALK oncogene is associated with what neoplasm

A

lung adenocarcinoma

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2
Q

BCR-ABL oncogene is associated with what neoplasm

A

CML, ALL

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3
Q

BCL-2 oncogene is associated with what neoplasm

A

follicular and diffuse large B Cell Lymphoma

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4
Q

BRAF oncogene is associated with what neoplasm

A

melanoma, NHL, papillary thyroid carcinoma, hairy cell leukemia

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5
Q

c-KIT oncogene is associated with what neoplasm

A

GIST

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6
Q

c-MYC oncogene is associated with what neoplasm

A

burkitt lymphoma

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7
Q

HER2/neu (c-erbB2) oncogene is associated with what neoplasm

A

breast and gastric carcinomas

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8
Q

JAK2 oncogene is associated with what neoplasm

A

chronic myeloproliferative disorders

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9
Q

KRAS oncogene is associated with what neoplasm

A

colon cancer, lung cancer, pancreatic cancer

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10
Q

MYCL1 oncogene is associated with what neoplasm

A

lung tumor

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11
Q

N-myc oncogene is associated with what neoplasm

A

neuroblastoma

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12
Q

RET oncogene is associated with what neoplasm

A

MEN 2A and 2B, papillary thyroid carcinoma, pheochromocytoma

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13
Q

APC tumor suppressor gene is associated with what condition

A

colorectal cancer (associated with FAP)

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14
Q

BRCA1/BRCA2 tumor suppressor gene is associated with what condition

A

breast, ovarian, and pancreatic cancers

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15
Q

CDKN2A tumor suppressor gene is associated with what condition

A

melanoma, pancreatic cancer

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16
Q

DCC tumor suppressor gene is associated with what condition

A

colon cancer

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17
Q

SMAD4 tumor suppressor gene is associated with what condition

A

pancreatic cancer

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18
Q

MEN1 tumor suppressor gene is associated with what condition

A

MEN type 1

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19
Q

NF1 tumor suppressor gene is associated with what condition

A

neurofibromatosis type 1

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20
Q

NF2 tumor suppressor gene is associated with what condition

A

neurofibromatosis type 2

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21
Q

PTEN tumor suppressor gene is associated with what condition

A

prostate, breast, endometrial cancers

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22
Q

Rb tumor suppressor gene is associated with what condition

A

retinoblastoma, osteosarcoma

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23
Q

TP53 tumor suppressor gene is associated with what condition

A

most human cancers, Li-fraumeni syndrome (SBLA cancer syndrome - sarcoma, breast, leukemia, adrenal gland)

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24
Q

TSC1 tumor suppressor gene is associated with what condition

A

tuberous sclerosis

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25
TSC2 tumor suppressor gene is associated with what condition
tuberous sclerosis
26
VHL tumor suppressor gene is associated with what condition
von Hippel-Lindau dz
27
WT1 tumor suppressor gene is associated with what condition
wilms tumor
28
aflatoxins (aspergillus): - exposure - organ affected - impact
stored grains and nuts liver hepatocellular carcinoma
29
alkylating agents: - exposure - organ - impact
oncologic chemotherapy blood leukemia/lymphoma
30
aromatic amines (benzidine, 2-naphthylamine) - exposure - organ affected - impact
textile industry, cigarette smoke bladder transitional cell carcinoma
31
arsenic - exposure - organ affected - impact
herbicides, metal smelting liver, lung, skin angiosarcoma, lung cancer, squamous cell carcinoma
32
asbestos - exposure - organ affected - impact
old roofing material, shipyard workers lung bronchogenic carcinoma \> mesothelioma
33
ionizing radiation - organ affected - impact
thyroid papillary thyroid carcinoma, leukemia
34
nickel, chromium, beryllium, silica - organ affected - impact
lung lung cancer
35
nitrosamines - organ affected - impact
stomach gastric cancer
36
radon - exposure - organ affected - impact
byproduct of uranium decay, accumulates in basements lung lung cancer
37
vinyl chloride - exposure - organ affected - impact
used to make PVC pipes liver angiosarcoma
38
EBV is associated with what cancers
burkitt lymphoma HL nasopharyngeal carcinoma primary CNS lymphoma
39
HBV, HCV is associated with what cancers
hepatocellular carcinoma
40
HHV-8 is associated with what cancers
kaposi sarcoma
41
HPV is associated with what cancers
cervical and penile/anal carcinoma, head and neck cancer
42
H. pylori is associated with what cancers
gastric adenocarcinoma and MALT lymphoma
43
HTLV-1 is associated with what cancers
adult T cell leukemia/lymphoma
44
liver fluke (clonorchis sinensis) is associated with what cancers
cholangiocarcinoma
45
schistosoma haematobium is associated with what cancers
squamous cell bladder cancer
46
alkaline phosphatase can be a marker for what conditions
mets to bone or liver paget dz of bone seminoma
47
alpha-fetoprotein can be a marker for what conditions
hepatocellular carcinoma endodermal sinus (yolk sac) tumor mixed germ cell tumor ataxia-telangectasia neural tube defects
48
hCG can be a marker for what conditions
hydatidiform moles and choriocarcinomas testicular cancer
49
CA 15-3/CA 27-29 can be a marker for what conditions
breast cancer
50
CA 19-9 can be a marker for what conditions
pancreatic adenocarcinoma
51
CA 125 can be a marker for what conditions
ovarian cancer
52
calcitonin can be a marker for what conditions
medullary thyroid carcinoma
53
CEA can be a marker for what conditions
colorectal and pancreatic cancers
54
chromogranin can be a marker for what conditions
neuroendocrine tumors
55
LDH can be a marker for what conditions
testicular germ cell tumors ocarian dysgerminoma
56
neuron-specific enolase can be a marker for what conditions
neuroendocrine tumors (small cell lung cancer, carcinoid tumor, neuroblastoma)
57
PSA can be a marker for what conditions
prostate cancer
58
Chromogranin and synaptophysin stain - what is the target - what tumors can be identified
neuroendocrine cells small cell carcinoma of the lung and carcinoid tumor
59
cytokeratin stain - what is the target - what tumors can be identified
epithelial cells epithelial tumors (squamous cell carcinoma)
60
Desmin stain - what is the target - what tumors can be identified
muscle muscle tumors (rhabdomuyosarcoma)
61
GFAP stain - what is the target - what tumors can be identified
neuroglia (astrocytes, schwann cells, oligodendrocytes) astrocytoma, glioblastoma
62
neurofilament stain - what is the target - what tumors can be identified
neurons neuronal tumors (neuroblastoma)
63
PSA stain - what is the target - what tumors can be identified
prostatic epithelium prostate cancer
64
S-100 stain - what is the target - what tumors can be identified
neural crest cells melanoma, schwannoma, langerhans cell histiocytosis
65
TRAP stain - what is the target - what tumors can be identified
tartrate-resistant acid phosphatase hairy cell leukemia
66
vimentin stain - what is the target - what tumors can be identified
mesenchymal tissue (fibroblasts, endothelial cells, macrophages) mesenchymal tumors (sarcoma), other tumors (endometrial carcinoma, RCC, meningioma)
67
psammoma bodies are seen in:
PSaMMOMa P: papillary carcinoma of thyroid S: somatostatinoma M: meningioma M: malignant mesothelioma O: ovarian serous papillary cystadenocarcinoma M: prolactinoma (milk)
68
the paraneoplastic syndrome dermatomyositis is associated with what tumors
adenocarcinomas (ovarian)
69
the paraneoplastic syndrome acanthosis nigricans is associated with what tumors
gastric adenocarcinoma and other visceral malignancies
70
the paraneoplastic sign of Leser-Trelat is associated with what tumors
GI adenocarcinomas and other visceral malignancies
71
the paraneoplastic syndrome hypertrophic asteoarthropathy is associated with what tumors
adenocarcinoma of the lung
72
hypercalcemia is associated with what tumors
squamous cell carcinomas of lung, head, and neck bladder, breast, ovarian carcinomas lymphoma
73
cushing syndrome is associated with what tumors
small cell lung cancer
74
hyponatremia (SIADH) is associated with what tumors
small cell lung cancer
75
polycythemia is associated with what tumors
pheochromocytoma, RCC, HCC, hemangioblastoma, leiomyoma
76
pure red cell aplasia is associated with what tumors
thymoma
77
good syndrome is associated with what tumors
thymoma
78
trousseau syndrome is associated with what tumors
adenocarcinomas, especially pancreatic
79
nonbacterial thrombotic (marantic) endocarditis is associated with what tumors
adenocarcinomas, especially pancreatic
80
Anti-NMDA receptor encephalitis is associated with what tumors
ovarian teratoma
81
opsoclonus-myoclonus ataxia syndrome is associated with what tumors
neuroblastoma (children) small cell lung cancer (adults)
82
paraneoplastic cerebellar degeneration is associated with what tumors
small cell lung cancer gynecologic and breast cancers HL
83
paraneoplastic encephalomyelitis is associated with what tumors
small cell lung cancer
84
lambert-eaton myasthenic syndrome is associated with what tumors
small cell lung cancer
85
myasthenia gravis is associated with what tumors
thymoma

Maddy - First Aid (23 decks)

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