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Flashcards in ‼️Patho-Endocrine Deck (25):
1

Morphology of pituitary adenoma

Uniform
Polygonal cells
Absence of significant reticulin networks

2

Most frequent type of hyperfunctioning pituitary adenoma

Prolactinoma

3

Second most common type of functioning pituitary tumor

Somatotroph adenoma

4

Test for elevated somatotropin

Glucose suppression of GH

5

Differentiate cushing disease from cushing's syndrome

Cushing syndrome - excess ACTH
Cushing disease - if pituitary source of ACTH

6

What is nelson's syndrome

Rebound enlargement of a pituitary adenoma in response to removal of the adrenals in patients with Cushing syndrome

7

Component of MEN 1

Pituitary adenoma
Hyperparathyroidism
Pancreatic tumor

8

Triad of pituitary apoplexy

Headache
Diplopia
Hypopituitarism

9

Sudden hemorrhage into the pituitary gland

Pituitary apoplexy

10

Most common cause of hyperpituitarism

Adenoma

11

Drugs that can cause nephrogenic diabetes insipidus

Lithium
Demelocycline

12

Findings in CDI and NDI after injection of ADH

CDI, Uosm inc >50 % frm baseline
NDI, Uosm inc

13

Treatment for CDI and NDI

CDI desmopressin
NDI thiazides or indomethacin

14

MCC of SIADH

Small cell lung CA (paraneoplastic)

15

Paraneoplastic effects of Lung SCCA

Hypercalcemia
Hyeperparathyroidism

16

Main drugs that can cause SIADH

Chlorpropramide

17

Clinical presentation of SIADH

Mental dysfunction due to cerebral edema
Hyponatremia

18

Treatment for SIADH

Water restriction

19

MCC of hypopituitarism in children

Craniopharyngioma

20

A craniopharyngioma is derived from

Rathke's pouch remnants

21

Mutation in craniopharyngioma

WNT signaling pathway

22

Most often observed craniopharyngioma in kidd

Adamantinimatous (spongy reticulum, wet keratin lamellae, peripheral palisading)

Adults - Papillary (lack keratin, calcification, cysts)

23

Most common cause of hypothyroidism

Hashimoto's

24

Hashimoto's is associated with what mutation

CTL4 polymorphisms

25

Autoantibodies in hashimoto's

Anti thyroglobulin
Anti-TPO