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Flashcards in ✅Patho- Pedia Deck (42):
1

Example of disruption

Amniotic bands

2

Define disruption

Secondary destruction of a structure that was normal in development

3

Example of deformation

Club foot

4

Extrinsic disturbance of development

Deformation

5

Most common cause of deformation

Uterine compression

6

Most common cardiac defect in congenital rubella syndrome

PDA

7

Potter sequence (oligohydramnios)

Pulmonary hypoplasia
altered facies
Positioning defects of hands and feet
Breech

8

What test determine's whether respiration took place on a newborn before death?

Fodere's test
(Hydrostatic test)

9

What test involves floating of the stomach in water to determine the presence of air?

Breslau's test

10

Retrolental fibroplasia

Retinopathy of prematurity

11

Pathogenesis of necrotizing enterocolitis

Transluminal migration of bacteria

12

MC presentation of NEC

Bloody stools

13

Morphology of NEC

Pneumatosis intestinale
Bowel infarction
Post NEC strictures

14

Two forms of fetal hydrops

Immune
Non-immune

15

Immune hydrops is usually caused by

Hemolytic disease

16

Non immune hydrops is usually caused by

Cardiovascular defects
Chromosomal anomalies
Fetal anemia

17

Virus that can cause fetal hydrops

Prvovirus b19

18

Amount of bilirubin to develop kernicterus

>20mg/dl

19

When should rhogam be administered to prevent hydrops fetalis?

28 weeks aog, within 72 hours of delivery or following abortions

20

Morphology of hydrops

Compensatory hyperplasia of bone marrow
Erythroblastosis fetalis
Large chorionic villi
Kernicterus

21

Mutation of what is involved in PKU

Gene encoding phenylalanine hydroxylase

22

Imparts the mousy odor in PKU

Phenylacetic acid

23

Most common lethal genetic disease that affects caucasians

Cystic fibrosis

24

Tests for CF

Sweat chloride test

25

Mutation in CF

Deletion of three nucleotides coding for phenylalanine at amino acid position 508 and production of a defective CFTR

26

Most common cause of death among people with CF

Respiratory infection due to pseudomonas aeruginosa

27

Criteria for sudden infant death syndrome

Less than 1 yr old
No cause

28

Most common finding in sudden infant death syndrome

Multiple petechiae

29

Safest sleeping position for infants

Supine

30

Most common tumors of infancy

Hemangioma

31

Most common teratomas of childhood

Sacrococcygeal

32

Amplification of N-myc gene

Neuroblastoma

33

Most common extracranial solid tumor of childhood

Neuroblastoma

34

Neuroblastoma is derived from

Primordial neural crest cells

35

Faintly eosinophilic fibrillary material in neuroblastoma morphology

Neuropil

36

Definition of a rosette

Tumor cells concentrically arranged on a central space

37

Diseases with Homer-Wright rosettes

Neuroblastoma
Medulloblastoma
PNET

38

Tumors around a blood vessel

Perivascular rosette

Mainly in ependymomas

39

Most common primary renal tumor of childhood

Wilms

40

Mutation in wilms

WT1 gene

41

Morphology of wilms tumor

Triphasic combination of

Blastemal
Stromal
Epithelial cell types

42

Primary errors of morphogenesis

Malformations