Patho-RBC and Bleeding Disorders Flashcards Preview

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Flashcards in Patho-RBC and Bleeding Disorders Deck (23):
1

Erythropoeitin level in hemolytic anemias

Increased

2

Most common cause of IDA overall?

GI bleeding

3

Intrinsic hemolysis is caused by

Intrinsic defects in rbc

4

How do u differentiate extravascular from intravascular hemolysis?

Extravascular hemolysis has splenomegaly

5

What is the expected morphology on peripheral blood smear of hemolytic anemias?

Normicytic normochromic

6

Hereditary spherocytosis is brought about by what mutations

Ankyrin
Spectrin
Band 3
Band 4.2

7

In a patient with hereditary spherocytosis, infection with parvovirus b19 can cause?

Infection with EBV?

Parvo - aplastic crisis
EBV- hemolytic crisis

8

Small dark nuclear remnants present in RBCs of asplenic patients

Howell-jolly bodies

9

G6pd is the rate limiting step in which biochemical pathway?

Pentose phosphate pathway

10

What is the function of G6PD

Reduces NADP to NADPH; provides reducing equivalents

11

Morphology G6PD deficiency

Heinz bodies
Bite cells

12

What are heinz bodies?

Membrane bound precipitates on denatured globin chains

13

Mutation in sickle cell anemia

Point mutation in 6th codon of beta globin

Leads to

Replacement of glutamate with VALINE

14

Dehydrated RBCs with bulls eye apoearance seen in sickle cell disease

Codocytes

15

Why are infants with sickle cell disease asymptomatic until 2-4 mos of age?

Due to high fetal hemoglobin F

16

Crises in Sickle cell anemia

Vasoocclusive crisis
Sequestration crisis
Aplastic crisis

17

Most common manifestation of vasoocclusive crisis in sickle cell anemia?

Hand foot syndrome
Inflammation of finger and toe

18

Massive entrapment of sickle cells leads to rapid splenic enlargement, hypovolemia, and shock

Sequestration crisis

19

Renal manifestation of sickle cell anemia

Hyposthenuria

Inability to concentrate urine

20

Signs of extramedullary hematopoieisis in sickle cell

Crew cut skull
Prominent cheekbones

21

What is the best initial diagnostic test for sickle cell anemia?

PBS

Not used in newborns

22

What is the drug of choice for sickle cell anemia and what is its mechanism of action?

Hydroxyurea (increases HbF)

23

Diagnostic gold standard for sickle cell anemia

Hemoglobin electrophoresis