✅Patho-Neoplasia Flashcards Preview

PTHO > ✅Patho-Neoplasia > Flashcards

Flashcards in ✅Patho-Neoplasia Deck (76):
1

Non neoplastic overgrowth of disorganized tissue indigenous to a particular site

Hamartoma

2

Non-neoplastic tissue in a foreign location

Choristoma

3

Syndrome with hamartomas

Peutz jeghers syndrome

4

Fibrous tissue formation in response to neoplasm

Desmoplasia

5

Mutations cause sustained activity of genes

Proto-oncogenes

6

Mutations cause unregulated cell proliferation

Tumor suppressor genes

7

Name the protooncogene involved.

CML

Abl

8

Name the protooncogene involved.

Burkitt's lymphoma

C-myc

9

Follicular and undiferrentiated lymphomas

Bcl-2

10

Name the protooncogene involved.

Breast, ovarian and gastric carcinomas

Erb-B2

11

Name the protooncogene involved.

Colon carcinoma

ras

12

Name the protooncogene involved.

Lung cancer

L-myc

13

Name the protooncogene involved.

Neuroblastoma

N-myc

14

Name the protooncogene involved.

MEN II and III

Ret

15

Name the protooncogene involved.

GIST

C-kit

16

Name the tumor suppressor gene and chromosome involved:

Retinoblastoma, osteosarcoma

Rb 13q

17

Name the tumor suppressor gene and chromosome involved:

Breast and ovarian cancer

BRCA1 17 mq
BRCA2 13q

18

Most human cancers, li-fraumeni syndrome

P53
17p

19

Name the tumor suppressor gene and chromosome involved:

Melanoma

P16
9p

20

Name the tumor suppressor gene and chromosome involved:

Colorectal CA associated with FAP

APC 5q

21

Name the tumor suppressor gene and chromosome involved:

Wilm's tumor

WT1
11p

22

Name the tumor suppressor gene and chromosome involved:

NF1 and NF2

NF1 17q
NF2 22q

23

Name the tumor suppressor gene and chromosome involved:

Pancreatic ca

DPC 18q

24

Name the tumor suppressor gene and chromosome involved:

Colon cancer

DCC 18q

25

TNM staging is more for

Prognostication

26

Cancers in children

ALL
CNS
Burkitt's lymphoma

27

Cancers in men

Prostate
Lung
Colorectal

28

Cancers in women

Breast
Lung
Colorectal

29

Cancers that cause the most mortality in men

Lung
Prostate
Colorectal

30

Cancers that cause the most mortality in women

Lung
Breast
Colorectal

31

Malignant tumors ending with "oma"

Hepatoma
Seminoma

32

What are the malignancies associated wity tuberous sclerosis

Astrocytoma
Angiomyolipoma
Cardiac rhabdomyoma

33

Malignancy associated with actinic keratoses

SCCA

34

Malignancy assoc with plummer vinson syndrome

SCCA of the esophagus

35

Malignancy associated with paget's disease of the bone

Secondary osteosarcoma
Fibrosarcoma

36

Malignancy asociated with immunodeficiency states

Malignant lymphoma

37

Malignancy associated with autoimmune diseases

Lymphoma

38

Malignancy assoc with acanthosis nigricans

Visceral malignancy

39

Malignancy assoc with radiation exposure

Sarcoma
Papillary thyroid CA

40

Most common cancers in China
Identify the cause.

Nasopharyngeal CA due to EBV

41

Most common cancers in Japan
Identify the cause.

Gastric adenoca
Smoked food

42

Most common cancers in SEA
Identify the cause.

HCCA
HBV and aflatoxin

43

Aflatoxin is from

A. Flavus

44

Most common cancers in Africa
Identify the cause.

Burkitt's lymphoma
EBV

45

Cachexia in CA is due to

TNF alpha

46

What are paraneoplastic syndromes

Distant effects of a tumor unrelated to metastasis

47

Chemical carcinogens

Vinyl chloride

Liver abgiosarcoma

48

Chemical carcinogens

CCl4

Centrilobular necrosis, fatty liver

49

Chemical carcinogens

Nitrosamines

Esoohagus stomach CA

50

Chemical carcinogens

Bronchogenic CA
Mesothelioma

51

Chemical carcinogens

Arsenic

SCCA skin
Liver angiosarcoma

52

Chemical carcinogens

Naphthalene (aniline) dyes

Transitional cell ca bladder

53

Chemical carcinogens

Alkylating agents

Blood (leukemia)

54

Associated cancer and infectious agent

Liver fluke

Cholangiocarcinoma

Chlonorchis sinensis
Opisthorchis viverrini

55

Associated cancer and infectious agent

Peptic ulcer disease

Gastric adenoca
MALT lymphoma

H pylori

56

Associated cancer and infectious agent

Chronic cystitis

Bladder SCCA

Schistosoma haemotobium

57

What CA of the lung is notorious for endocrinopathies?

Small cell cA

Acth adh pthrp

58

Name the clinical syndrome of the underlying cancer

Lung CA

Lanbert-eaton myasthenia

59

Name the clinical syndrome of the underlying cancer

Visceral ca

Acanthosis nigricans

60

Name the clinical syndrome of the underlying CA

Pancreatic CA

Trousseau syndrome

61

Name the clinical syndrome of the underlying CA

Thymoma

Red cell aplasia

62

Name the clinical syndrome of the underlying CA

Hodgkin's lymphoma

Nephrotic syndrome

63

Electrolyte abnormalities in tumor lysis syndrome

Hyperkalemia
Hyperuricemia
Hyperphosphatemia
HYPOCALCEMIA

64

CA with brain mets

Lung
Breast
Skin (melanoma)
Kidney (renal cell ca)
GI

Mnemonic: LOTS OF BAD STUFF KILL GLIA

65

Liver metastasis occur in which CA

Colon
Stomach
Pancreas
Breast
Lung

Cancer sometimes penetrate benign liver

66

Bone mets in CA

Prostate (blastic)
Thyroid (follicular)
Testes
Breast (both lytic and blastic)
Lung (lytic)
Kidney

67

Tumor marker

Prostate CA

PSA

68

Tumor marker

Hepatocellular CA

AFP

69

Tumor marker

Colorectal CA
Pancreatic , GI, breast CA

CEA

70

Tumor marker

Hydatidoform mole
ChorioCA
GEstational trophoblastic tumor

B HCG

71

Tumor marker

Ovarian
Malignant epithelial CA

Ca-125

72

Tumor marker

Mets to bone
Obstructive biliary disease
Pagets disease of the bone

Alk phos

73

Tumor marker

Melanoma
Neural tumors
Astrocytomas

S-100

74

Tumor marker

Neuroblastoma

Bombesin

75

Tumor marker

Hairy cell leukemia

TRAP

76

Tumor marker

Panc CA

CA 19-9