Pathology - Melanocytic Flashcards
what turns phaeomelanin into eumelanin?
MC1R
one defective copy of MC1R causes what?
two defective copies of MC1R causes what?
1 - freckling
2 - red hair and freckling
what is the other word for freckles?
ephilides
actinic lentigines is also known as what?
‘age’ or ‘liver’ spots
give the sizes of the following congenital melanocytic naevi:
(a) small
(b) medium
(c) large
(a) small <2cm
(b) medium 2-20cm
(c) large >20cm
name the 3 types of naevus
junctional
compound
intradermal
what stages in life do the following naevus occur:
junctional
compound
intradermal
junctional - childhood
compound - adolescence
intradermal - adulthood
where are the melanocytes located in a junctional naevus?
DEJ
compound - DEJ and dermis
intradermal - dermis
name the 2 types of dysplastic naevi
sporadic and familial
what is there a strong FHx of in familial DN?
melanoma
CDKN2A
what is not affected in DN?
epidermis
epidermis involvement in melanoma
naevi that are surrounded by a ring of depigmentation are called what?
halo naevi
what is the naevi called that is entirely dermal and consist of pigment rich dendritic spindle cells?
blue naevi
they mimic melanoma
name the rare naevus described by epidermal hyperplasia and closely mimic melanoma consisting of large spindle and/or epithelioid cells
Spitz naevus
melanoma is commoner in which sex?
female
