Flashcards in Pathology of the Thyroid Deck (38)
For what disease are pts with Hashimoto thyroiditis at an increased risk?
- B CELL Non-Hodgkin LYMPHOMA, bc you are generating post-germinal center B cells, which eventually form a MARGINAL ZONE.
*** What is Subacute (deQuervain) Granulomatous Thyroiditis?
- granulomatous thyroiditis that follows a viral infection.
- NEUTROPHILIC infiltrate.
- presents as TENDER/PAINFUL THYROID with transient hyperthyroidism.
- self-limited (does NOT progress to HYPOthyroidism) :)
What is Reidel Fibrosing Thyroiditis?
- chronic inflammation with extensive asymmetric fibrosis of thyroid.
- presents as HYPOthyroidism with 'HARD as WOOD,' nontender thyroid gland.
*classically a YOUNG FEMALE.
To where may fibrosis extend in Reidel Fibrosing Thyroiditis?
- local structures (e.g. airway).
If you had the same presentation as Reidel Fibrosing Thyroiditis, but in an older pt, what would you think instead?
- anaplastic carcinoma of the thyroid
What is the most common cause for CONGENITAL HYPOthyroidism?
- IODINE DEFICIENCY
What is ACQUIRED HYPOthyroidism?
- surgical or radiation induced ablation of the thyroid.
- drugs given intentionally to decrease thyroid secretion.