Pathology of the Thyroid Flashcards Preview

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Flashcards in Pathology of the Thyroid Deck (38)
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31

For what disease are pts with Hashimoto thyroiditis at an increased risk?

- B CELL Non-Hodgkin LYMPHOMA, bc you are generating post-germinal center B cells, which eventually form a MARGINAL ZONE.

32

*** What is Subacute (deQuervain) Granulomatous Thyroiditis?

- granulomatous thyroiditis that follows a viral infection.
- NEUTROPHILIC infiltrate.
- presents as TENDER/PAINFUL THYROID with transient hyperthyroidism.
- self-limited (does NOT progress to HYPOthyroidism) :)

33

What is Reidel Fibrosing Thyroiditis?

- chronic inflammation with extensive asymmetric fibrosis of thyroid.
- presents as HYPOthyroidism with 'HARD as WOOD,' nontender thyroid gland.
*classically a YOUNG FEMALE.

34

To where may fibrosis extend in Reidel Fibrosing Thyroiditis?

- local structures (e.g. airway).

35

If you had the same presentation as Reidel Fibrosing Thyroiditis, but in an older pt, what would you think instead?

- anaplastic carcinoma of the thyroid

36

What is the most common cause for CONGENITAL HYPOthyroidism?

- IODINE DEFICIENCY

37

What is ACQUIRED HYPOthyroidism?

- surgical or radiation induced ablation of the thyroid.
- drugs given intentionally to decrease thyroid secretion.

38

What normally causes a goiter?

- dietary deficiency of iodine. TSH rises in an attempt to make more thyroid hormone, leading to hypertrophy.