Patterns of Liver Injury 2 - Chronic Hepatitis Flashcards Preview

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Flashcards in Patterns of Liver Injury 2 - Chronic Hepatitis Deck (20):
1

What is chronic hepatitis?

persistence of liver injury with raised serum aminotransferase levels for more than 6 months

2

What causes chronic hepatitis?

chronic HBV and HCV, autoimmune hepatitis, drugs

3

Do all patients with chronic elevation of liver enzymes have chronic hepatitis?

no - may be non alcoholic fatty liver disease - need biopsy to confirm diagnosis

4

What are the symptoms of chronic hepatitis?

may have no symptoms - or may have few symptoms like fatigue and loss of appetite

5

What are the histological features of chronic hepatitis?

portal tract is heavily infiltrated by lymphocytes and show interface hepatitis (where lymphocytes spill over into periportal tissue)

6

What determines the grade of chronic hepatitis?

degree of interface hepatitis

7

Is interface hepatitis specific for chronic hepatitis?

no - but it is a hallmark feature

8

What is the pattern of fibrosis in chronic hepatitis?

bands that radiate outward from the portal tract

9

What determines the stage of chronic hepatitis?

the degree of fibrosis - stage 1 to stage 4 (stage 4 is cirrhosis)

10

What happens in the progression of fibrosis in chronic hepatitis?

Starts of as enlarged portal tract, then strands of collagen extend towards central vein, then get bridging of fibres and eventual get fibrous tissue contraction, loss of normal anatomical structure and cirrhosis

11

What is non alcoholic fatty liver disease?

steatosis with or without steatohepatitis and fibrosis

12

What are the associations of NAFLD?

obesity, metabolic syndrome, diabetes

13

What is steatosis?

an accumulation of abnormal amount of lipid in hepatocytes

14

What are the two types of steatosis?

macrovesicular (common) and micro vesicular (rare)

15

What causes macro vesicular steatosis?

increased triglyceride synthesis - caused either by obesity or alcohol

16

What is steatohepatitis?

steatosis accompanied by inflammation and hepatocyte injury - at risk of fibrosis

17

What is the hallmark feature of steatohepatitis?

hepatocellular ballooning

18

How do you determine whether the liver has steatohepatitis or alcoholic hepatitis?

Clinical diagnosis - histological features are identical

19

What is the pattern of fibrosis in non alcoholic steatohepatitis (NASH)?

pericellular fibrosis- ‘chicken wire fibrosis’

20

What causes the inflammation in NASH?

hepatocellular free fatty acids develop into lipotoxic metabolites because they can no longer be converted to triglycerides as the pathway is overloaded (due to diet and insulin resistance)