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Flashcards in Pharm 2 - Exam 1 Deck (88)
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1

Which opioid receptor site is for pain?

Mu

2

These receptor sites are found throughout the body and can lead to many systemic effects.

Opioid

3

This opioid analgesic has a high affinity for mu receptors and is known to blunt perception.

Morphine/ MS Contin

4

This drug might be used in the case of pain, anxiety and acute MI due to its vasodilatory effect.

Morphine/MS Contin

5

Respiratory depression is the most common cause of death related to this drug.

Morphine/MS Contin

6

These three s/sx are an indicator of opiate analgesic use.

pinpoint pupils
itching
respiratory depression

7

How do opiates cause constipation or even paralytic ileus?

Mu receptors in the GI are stimulated and reduce GI motility.

8

Which are the routes of administration for morphine?

IV, PO, rectal

9

This drugs has 80x the analgesic strength of morphine.

Fentanyl/Duragesic

10

What are the routes of administration for Fentanyl/Duragesic?

IV, transdermal patch, buccal lozenge, sublingual spray, LOLLIPOP

11

Patients using concomitant CYP450 inhibitors are at risk for fatal blood level of this drug.

Fentanyl/Duragesic

12

Fentanyl/Duragesic patches can be rendered less effective/not work as intended by doing what two things?

cutting the patch in half
placing heat over the patch

13

This opiate analgesic is also an effective antitussive.

Codeine

14

Which opiate analgesic prescription can be called in?

Codeine

15

This centrally-acting analgesic also affect neurotransmitters and so may improve mood.

Tramadol/Ultram

16

Spell the common name of Diacetylmorphine.

H-E-R-O-I-N (there is no E)

17

Name the synthetic opioid that is used to control withdrawal from heroin and morphine.

Methadone

18

This drug is known for the rapid reversal of opiate effects in addicted patients.

Nalaxone/Narcan

19

This drug is the dextro-isomer of codeine.

Dextromethorphan (DM)

20

What compounds do NSAIDs prevent the synthesis of?

prostaglandins (via COX-1 and COX-2)

21

Name the COX-2 inhibitor

Celecoxib/Celebrex

22

Does aspirin reversibly/irreversibly inhibit COX-1?

Irreversibly

23

What medications can be used for migraine prophylaxis?

Beta-blockers, Ca Channel Blockers, Methysergide, Tricyclic antidepressants, ergotamine, anti-seizure medications

24

Which medication is used during the prodromal phase of migraine management?

Triptans (mc Sumatriptan/Imitrex)

25

Which medications are used for the actual headache phase of the migraine?

Analgesics
Anti-emetics

26

Name the drug and class of beta blocker (selective/non-selective) that is used for migraine prophylaxis.

Non-selective, e.g. Propranolol/Inderal

27

This tricyclic antidepressant is used in the treatment of migraine/tension HA.

Amitriptyline/Elavil

28

This anticonvulsant is used for the treatment of migraines and may also be used for weight loss and for drug withdrawal.

Topiramate/Topamax

29

Methysergide/Sansert is an ergot derivative - serotonin 2 receptor ____________ (agonist/antagonist), therefore causing ____________ (vasodilation/vasoconstriction.)

Antagonist
Vasoconstriction

30

What are the three most concerning side effects of Methysergide/Sansert?

1. vasoconstriction
2. pulmonary fibrosis and retroperitoneal fibrosis
3. heart valve thickening >>> murmurs