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Flashcards in Pharm 2 - Extra Cards for Final Deck (46)
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1

In what class of drugs is Tetrahydrozoline/Visine?

Ocular astringent, redness reliever

2

What is the MOA of Tetrahydrozoline/Visine?

Vasoconstriction

3

Name the Ocular Antihistamine drug.

Azelastine/Optivar

4

What is the MOA of Azelastine/Optivar?

Blocks H1 receptor sites

5

In what class of drugs is Ketorolac/Acular?

Ocular NSAID

6

What is the MOA of Ketorolac/Acular?

COX inhibitor

7

T/F. The use of ocular NSAIDS has increased risk for development of cataracts and drug induced glaucoma

False
These risks are associated with ocular steroids

8

What is the MOA of Bacitracin-Polymyxin B/Polysporin Ophthalmic?

Inhibits bacterial protein synthesis

9

Name the antiviral drug specifically used for HSV keratoconjunctivitis.

Vidarabine/Ara-A

10

What is the MOA for Vidarabine/Ara-A?

Inhibits viral DNA synthesis

11

What is the MOA of Timolol/Timoptic?

Blocks the ocular effects of epinephrine which serve to reduce the production of the aqueous humor.

12

When is Timolol/Timoptic used and in what class is it found?

Glaucoma
Ocular Beta-adrenergic antagonist

13

Which drug has SE (when absorbed systemically) that include worsening of asthma or emphysema, low blood pressure, fatigue, impotence?

Timolol/Timoptic

14

Latanoprost/Xalantan is a selective prostaglandin receptor _________ (agonist/antagonist).

Agonist

15

This drug may cause heterochromia, lengthening, thickening and darkening of the eyelashes.

Latanoprost/Xalantan

16

What is the MOA of Latanoprost/Xalantan?

binds to prostaglandin receptor leading to improved aqueous humor outflow and reducing intraocular pressure.

17

What immunosuppressive drug is used in the eye in low doses as a wetting agent?

Cyclosporine

18

What is the MOA of Cyclosporine as a wetting agent?

T-cell inhibition reduces inflammation, allowing for an increase in tear production.

19

What factors may increase topical drug penetration?

Decreased drug molecule size
Increased lipid content
Increased drug concentration within topical agent
Decreased skin integrity

20

In what class of drugs is Polymyxin B - Neomycin - Bacitracin/Neosporin?

Topical antimicrobial

21

What is the MOA of Polymyxin B-Neomycin-Bacitracin/Neosporin?

Bacteriacidal.
Polymyxin disrupts bacterial cell membrane.
Bacitracin disrupts bacterial cell wall.
(No mention of neomycin MOA)

22

T/F. Polymyxin B-Neomycin-Bacitracin/Neosporin is safe to use as an otic solution when there is a perforated TM.

False. Polymyxin B-Neomycin-Bacitracin/Neosporin as an otic solution should be avoided with perforated TM due to ototoxicity of Neomycin.

23

Which topical agent is typically used for impetigo and other skin infections caused by bacteria, especially Staph and Strep?

Mupirocin/Bactroban

24

What is the MOA of Mupirocin/Bactroban?

Inhibits bacterial protein synthesis

25

Which topical antibiotic may be used in combination with oral or IV antibiotics to treat MRSA?

Mupirocin/Bactroban

26

In what class of drugs is Ketoconazole/Nizarol, and what conditions might it treat?

Topical antifungal
Tx for superficial fungal infxns such as tinea pedis, tines cruris, tinea corporis (ringworm), superficial yeast infxns, and seborrheic dermatitis.

27

What is the MOA of Ketoconazole/Nizarol?

Inhibits sterol synthesis

28

How many (numbered) classes of topical glucocorticoids are there? Which is the most potent?

7 different classes, numbered 1-7
Class 1 is most potent
Class 7 is least potent

29

T/F. Halogenated corticosteroids are generally the most potent topical steroids.

True

30

T/F. Halogenated corticosteroids are awesome to use on the face.

False. Perioral dermatitis and rosacea may occur upon discontinuation.