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Flashcards in Pharm 2 - Exam 3 Deck (141)
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1

Which thyroid hormone(s) does Levothyroxine/Synthroid replace?

T4

2

Which thyroid hormone(s) does Thyroid USP/Armour thyroid replace?

T4 and T3

3

Which thyroid hormone(s) does Liothyronine/Cytomel replace?

T3

4

Which form of thyroid hormone is active?

T3

5

What is the normal T4:T3 ratio?

4:1

6

If a patient has Addison's Disease and hypothyroidism, which disease must be addressed first in terms of treatment with medication?

Addison's. Replace cortisol before replacing thyroid hormone.

7

In what unit doses are Armour and Synthroid given?

Armour: mg
Synthroid: mcg

8

60mg of Thyroid USP/Armour is equivalent to how much Levothyroxine/Synthroid and how much Liothyronine/Cytomel?

100mcg Levothyroxine/Synthroid
25mcg Liothyronine/Cytomel

9

Long term elevation of T4 (such as from Levothyroxine/Synthroid use) increases the risk of what two pathologies?

Osteoporosis
CVD

10

This hypothyroid med is also indicated for Wilson's Syndrome.

Liothyronine/Cytomel (T3)

11

In what class of drugs are Methimazole/Tapazole and PTU?

Thionamide

12

What is the MOA of Methimazole/Tapazole and PTU?

Blocks conversion of T4 to T3

13

What is the most feared side effect of Methimazole/Tapazole and PTU?

agranulocytosis

14

What is the result of super physiologic doses of iodine?

stuns the thyroid into inactivity for days to weeks

15

Name the two thionamide drugs.

Methimazole/Tapazole
Propylthiouricil (PTU)

16

Of the two thionamide drugs, which is most effective in preventing the conversion of T4 to T3 in peripheral tissues?

PTU

17

What is the MOA of the thionamide drugs?

1. inhibits conversion of inorganic iodine to organic iodine which prevents the formation of thyroxine.
2. blocks the coupling of iodotyrosine, therefore stopping the production of T3 and T4

18

Which of the thionamide drugs is more appropriate for pregnancy?

PTU. Both are category D though.

19

Which drugs would be most appropriate for the treatment of thyroid storm?

Propanolol/Inderal
IV Iodine/SSKI

20

How long do the beneficial side effects of iodine/SSKI last?

2-3 weeks

21

Compare the onset of action and half-life of Levothyroxine/Synthroid to Liothyronine/Cytomel?

L/S: slow onset, half-life of ~1 week
L/C: rapid onset, half-life of several hours

22

How long is radioactive iodine typically in the body after a dose is taken?

3-5 days.

23

What is the drug classification of radioactive iodine?

category x

24

How long should pregnancy be delayed following radioactive iodine treatment?

6-12 months

25

What are the s/sx of a thyroid storm?

high fever, irritability, delerium, vomiting, diarrhea, hypotension, dehydration, vascular collapse

26

Diabetes diagnoses all rely on what form of testing?

Serum glucose

27

What might be the problem with calcium derived from oyster or bone?

Lead and other heavy metal contamination

28

What drug class requires that a patient is able to stand or sit upright for 30-60 minutes due to its propensity to cause inflammations and erosion of the esophagus?

bisphosphonates

29

In what class of drugs is Alendronate/Fosamax?

Bisphosphonates

30

What are the two major SE of Alendronate/Fosamax?

Osteonecrosis of the jaw
Atypical femur fractures (ex. in the shaft)