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Flashcards in Pharm 2 - Exam 2 Deck (71)
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1

Which two antidepressant drug classes should be considered for those with depression and insomnia?

TCA
Tetracyclic antidepressants

2

What is a serious side effect of MAOIs?

hypertensive emergencies

3

This class of antidepressants increases the likelihood of arrhythmias.

TCAs

(Also TeCAs, though far less common than with TCAs.)

4

Foods containing this amino acid should be avoided by those taking MAOIs.

Tyramine (require MAO to be broken down)

5

Name the Tetracyclic/SARI antidepressant.

Trazodone/Desyrel

6

What is the MOA of Trazodone/Desyrel?

Serotonin (partial) ANTAgonist and re-uptake inhibitor. (SARI)

7

In what class of drugs is Fluoxetine/Prozac?

SSRI

8

Name the SNRI drug.

Duloxetine/Cymbalta

9

Which drug is indicated for mild-moderate depression?

none

10

This anti-depression drug is also indicated for pain syndromes such as painful peripheral neuropathy and fibromyalgia.

Duloxetine/Cymbalta

11

Anti-depression drugs have the potential for increasing the risk of what in people with major depressive disorder?

suicide

12

In what class of anti-depression meds is Bupropion/Wellbutrin/Zyban?

Norepinephrine and dopamine reuptake inhibitors (NDRI) and nicotine receptor ANTAgonist

13

Why should barbiturates not be mixed with alcohol?

Can potentiate sedation and respiratory depression

14

T/F. Barbiturates and benzodiazepine receptor sites are the same location as GABA sites on the cell membrane of neurons in the CNS.

False. They appear to be adjacent to but NOT the same. The configuration of the GABA receptor site then changes (in response to the stimulation of the adjacent site) and the affinity for GABA of the GABA receptor site increases.

15

This long-acting barbiturate is the most widely used anticonvulsant worldwide.

Phenobarbital/Luminal

16

Name the short-acting barbiturate.

Pentobarbital/Nembutal

17

Name the intermediate-acting barbiturate.

Butalbital/Fiorinal

18

This short-acting benzodiazepine is used for sedation and anxiety prior to procedures. It also has amnestic properties.

Midazolam/Versed

19

What is the MOA for Diazepam/Valium?

Binds to benzodiazepine receptors in the CNS to enhance GABA activity

20

T/F. Zolpidem/Ambien and Eszopiclone/Lunesta use barbiturate and benzodiazepine receptors to enhance GABA activity.

False. Rather, benzodiazepine-like hypnotics bind to neither barbiturate and benzodiazepine receptors.

21

In what class of drugs is Ramelteon/Rozerem and how does it work?

Melatonin agonist
Mimics endogenous melatonin by binding to MT1 and MT2 receptor sites

22

Which drug can reverse the effects of benzodiazepine overdose?

Flumazenil/Romazicon

23

Tardive dyskinesia is a potential side effect for what class of drugs?

Neuroleptic antipsychotics

24

What symptoms are seen with neuroleptic malignant syndrome?

Catatonia, fluctuating blood pressure, dysarthria and fever

25

What is the treatment for neuroleptic malignant syndrome?

dopamine agonist such as Bromocriptine

26

In addition to anti-psycotic, what is another action of neuroleptic drugs?

anti-emetic, anti-nasuea

27

What are the major side effects of Chlorpromazine/Thorazine?

Parkinsonian symptoms
elevated prolactin

28

What is the class and MOA of both Chorpromazine/Thorazine and Prochlorperazine/Compazine?

typical neuroleptic
D2 receptor ANTAgonist, H1-histmaine receptor ANTagonist and alpha adrenergic receptor ANTagonist

29

What are the side effects of Prochlorperazine/Compazine?

anti-cholinergic: drowsiness, dry mouth, constipation, urinary hesitancy

30

What is the class and MOA of Haloperidol/Haldol?

Typical Neuroleptic
D2 dopaminergic receptor blocker