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Flashcards in Pharm10 - Pharm10 Deck (52)
1

MOA orlistat

inhibits pancreatic lipase

2

clinical use of orlistat

obesity management

3

toxcicity of orlistat

gi discomfort steatorrhea reduced absorption of fat soluble vitamins ha

4

MOA sibutramine

sympathommimetic 5HT and NorE reuptake inhibitor

5

uses of sibutramine

short term and long term obesity management

6

toxicity of sibutramine

htn tachycardia

7

uses of GH

GH deficiency turner's syndrome

8

uses of somatostatin

acromegaly carcinoid gastrinoma glucagonoma

9

uses of octeroitide

(aka somatostatin) acromegaly carcinoid gastrinoma glucagonoma

10

uses of adh

pituitary DI

11

MOA propylthiouracil

inhibits organification and coupling of thyroid hormone synthesis decreased peripheral conversion of T4 --> T3

12

Which drugs block peptidoglycan cross-linking

Cephalosporin -cillins -nam/-nem

13

which drugs block peptidoglycan synthesis?

bacitracin vancomycin cycloserine

14

which drugs block bacterial/fungal cell wall synth

polymyxins

15

which drugs disrupt fungal cell membranes

amphotericin b nystatin -azoles

16

which drugs block NT synth

'Try my cell phone - I blocked the New Cleo' Sulfonamides trimethoprim

17

which drugs block DNA synth

'TOPless DANcing Queen' (insert abba song here... :) Topoisomerase Quinolones

18

which drugs block mRNA synth

rifampin

19

Which drugs block protein synth at the 50S subunit?

-mycins linezolid -gramins macrolides chloramphenicol

20

which drugs block protein synth at the 30S subunit

Aminoglycosides tetracyclines

21

MOA penicillin

it binds to penicillin binding proteins blocks the cross-linking of peptidoglycan activates autolytic enzymes

22

uses for penicillin

gram + cocci and rods GNR spirochetes

23

which penicillins are the penicillinase resistant?

Nafcillin dicloxacillin methicillin

24

clinical uses for penicillinase resistant penicillins?

S. aureus (except for MRSA)

25

why are penicillinase resistant penicillins resistant to penicillinase

bulikier R group

26

how is MRSA resistant to methicillin

altered penicillin binding protein target site

27

adverse reaction to methicillin

interstitial nephritis

28

examples of aminopenicillins

ampicillin amoxicillin

29

what is clavulanic acid

penicillinase inhibitor

30

clinical uses for aminopenicillins

'ampicillin/amoxicillin HELPS kill enterococci' H. influenza e. coli Listeria monocytogenes Proteus mirabilis Salmonella Enterococci

31

anti-pseudomonal drugs

'Take Piper in the Car, Sue' ticarcillin piperacillin carbenicillin

32

MOA cephalosporins

same as penicillins, less susceptible to penicillinases

33

uses for 1st generation cephalosporins

PEcK Proteus E coli Klebsiella

34

uses for 2nd generation cephalosporins

HEN PEcKS H. flu Enterobacter Neisseria Proteus E. coli Klebsiella Serratia

35

examples of 1st generation cephalosporins

'You FAILed the FIRST PHASE' cefazolin cephalexin

36

examples of 2nd generation cephalosporins

'Wait a SECOND! You SEE, FOX FUR is a FACt' cefoxitin cefuroxime cefaclor

37

3rd generation cephalosporins

'If you are THIRsty, try a FOTO TAZER' Cefotaxime Ceftazidime ceftriaxone

38

clinical uses of aztreonam

klebsiella pseudomonas serratia (GNR only, nothing against gm + or anaerobes)

39

who is given aztreonam

penicillin allergic pts pts w renal insuff that can't tolerate aminoglycosides

40

what is cilastatin?

inhibits renal dihydropeptidase I always administered with imipenem

41

clinical uses for imipenem/meropenem?

gram + cocci GNR anaerobes

42

toxicity of imipenem, meropenem

gi distress rash seizures (all occcur at high plasma levels)

43

MOA aminoglycosides 'cidal/static?

inhibits formation of initiation complex --> misreads mRNA requires O2 for uptake, so won't work against anaerobes 'cidal

44

which drugs are aminoglycosides?

'Mean GNATS canNOT kill anaerobes' Gentamicin Neomycin Amikacin Tobramycin Streptomycin

45

toxicity of aminoglycosides

'Mean GNATS canNOT kill anaerobes' Nephrotoxicity (esp if used with cephalosporin) Ototoxicity (esp w/ loop diuretic) Teratogen

46

Uses for tetracyclines

VACUUM THe BedRoom Tunight V. cholera Acne Chlamydia Ureaplasma Urealyticum Mycoplasma pneumoniae Tularemia H. Pylori Borrelia Burgodorferi Rickettsia

47

MOA tetracyclines 'cidal/static?

binds 30S and prevents attachment of aminoacyl RNA static

48

foods to avoid when takin tetracyclines

don't take with milk, iron, or antacids b/c it will inhibit absorption in gut

49

which tetracycline is fecally eliminated?

doxycycline (can be used in renal failure)

50

toxicity of tetracyclines

photosensitivity gi discomfort discoloration of teeth inhibits bone growth in kids

51

contraindications of tetracyclines

pregnancy

52

what drug can act as a diuretic in SIADH

demeclocycline (ADH antagonist)