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Flashcards in Pharm10 - Pharm10 Deck (52)
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1

MOA orlistat

inhibits pancreatic lipase

2

clinical use of orlistat

obesity management

3

toxcicity of orlistat

gi discomfort steatorrhea reduced absorption of fat soluble vitamins ha

4

MOA sibutramine

sympathommimetic 5HT and NorE reuptake inhibitor

5

uses of sibutramine

short term and long term obesity management

6

toxicity of sibutramine

htn tachycardia

7

uses of GH

GH deficiency turner's syndrome

8

uses of somatostatin

acromegaly carcinoid gastrinoma glucagonoma

9

uses of octeroitide

(aka somatostatin) acromegaly carcinoid gastrinoma glucagonoma

10

uses of adh

pituitary DI

11

MOA propylthiouracil

inhibits organification and coupling of thyroid hormone synthesis decreased peripheral conversion of T4 --> T3

12

Which drugs block peptidoglycan cross-linking

Cephalosporin -cillins -nam/-nem

13

which drugs block peptidoglycan synthesis?

bacitracin vancomycin cycloserine

14

which drugs block bacterial/fungal cell wall synth

polymyxins

15

which drugs disrupt fungal cell membranes

amphotericin b nystatin -azoles

16

which drugs block NT synth

'Try my cell phone - I blocked the New Cleo' Sulfonamides trimethoprim

17

which drugs block DNA synth

'TOPless DANcing Queen' (insert abba song here... :) Topoisomerase Quinolones

18

which drugs block mRNA synth

rifampin

19

Which drugs block protein synth at the 50S subunit?

-mycins linezolid -gramins macrolides chloramphenicol

20

which drugs block protein synth at the 30S subunit

Aminoglycosides tetracyclines

21

MOA penicillin

it binds to penicillin binding proteins blocks the cross-linking of peptidoglycan activates autolytic enzymes

22

uses for penicillin

gram + cocci and rods GNR spirochetes

23

which penicillins are the penicillinase resistant?

Nafcillin dicloxacillin methicillin

24

clinical uses for penicillinase resistant penicillins?

S. aureus (except for MRSA)

25

why are penicillinase resistant penicillins resistant to penicillinase

bulikier R group

26

how is MRSA resistant to methicillin

altered penicillin binding protein target site

27

adverse reaction to methicillin

interstitial nephritis

28

examples of aminopenicillins

ampicillin amoxicillin

29

what is clavulanic acid

penicillinase inhibitor

30

clinical uses for aminopenicillins

'ampicillin/amoxicillin HELPS kill enterococci' H. influenza e. coli Listeria monocytogenes Proteus mirabilis Salmonella Enterococci