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Flashcards in Pharm4 - Pharm4 Deck (59)
1

MOA amphetamine

indirect general sympathetic agonist releases stored catecholamines

2

MOA epehderine

indirect and direct sympathomimetic stimulates release of NE from sympathetic neurons

3

MOA cocaine

blocks reuptake of NorE and DA

4

MOA clonidine

centrally acting alpha agonist decreased central adregnergic outflow

5

uses for epi

anaphylaxis glaucoma asthma hypotension

6

uses for norE

hypotension (but decreases renal perfusion)

7

uses for isoproterenol

rare... AV block

8

uses for DA

shock (increases renal perfusion) heart failure

9

uses for dobutamine

shock heart failure cardiac stress testing

10

uses for amphetamines

narcolepsy obesity ADD

11

uses for ephedrine

nasal decongestion urinary incontinence hypotension

12

uses for phenylephrine

pupil dilator vasoconstriction nasal decongestion

13

uses for albuterol

asthma

14

uses for terbutaline

asthma

15

uses for cocaine

vasoconstriction local anesthetic

16

uses for clonidine

HTN (esp with renal dz b/c it doesn't decrease blood flow to kidney)

17

examples of inhaled anesthetics

halothane enflurane isoflurane (-ane)

18

MOA inhaled anesthetics

unknown

19

effects of inhaled anesthetics

myocardial depression respiratory depression n/v increased cerebral blood flow decreased cerebral demand

20

toxicity of halothane

hepatotoxicity

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toxicity of methoxyflurane

nephrotoxicity

22

toxicity of enflurane

pro-convulsant

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toxicity of any inhaled anesthetic

malignant hyperthermia (rare)

24

types of drugs used as IV anesthetics

BB King on optiates proposes foolishly Barbiturates benzos Ketamine (arylclohxamines) opiates Propofol

25

which barbiturate is commonly used as an IV anesthetic?

thiopental

26

uses of thiopental

induction of anesthesia short surgical procedures

27

which is the most common anesthetic used for endoscopy? what is it administered with?

midazolam gaseous anesthetics and narcotics

28

side effects of midazolam

post-op respiratory depression hypotension amnesia

29

how is the respiratory depression from midazolam treated?

flumezanil

30

side effects of arylcyclohexamines

bad dreams CV stimulation disorientation hallucinations increased cerebral blood flow

31

benefit of propofol

less post-op nausea than thiopental

32

what is combined with opiates during general anesthesia?

other CNS depressants

33

MOA local anesthetics

block Na channels by binding to specific receptors in inner portion of channel

34

examples of atypical antipsychotics

olanzapine clozapine risperidone

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examples of typical antipsychotics

thioridazine haloperidol fluphenazine chlorpromazine

36

MOA typical antipsychotics

block D2 receptor

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MOA atypical antipsychotics

blocks dopamine and 5HT receptors

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clinical uses of typical antipsychotics

schizophrenia psychosis acute mania Tourette's

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clinical uses for atypical antipsychotics

schizophrenia (+ and - sx)

40

clinical uses for olanzapine

OCD anxiety d/o depression mania Tourette

41

toxicity associated with typical antipsychotics

EPS endocrine effects anti-muscarinic effects (dry mouth) hypotension (from blocking alpha receptors), sedation (from blocking histamine receptors) NMS tardive dyskinesia

42

what is tardive dyskinesia

stereotypical oral-facial movements d/t blocking DA receptors

43

what is NMS

rigidity myoglobinuria autonomic instability hyperpyrexia

44

tx of NMS

dantrolene and DA agonists

45

toxicity associated wiht atypical antipsychotics

less EPS and anti-cholinergic effects Clozapine --> agranulocytosis

46

uses for lithium

bipolar blocks relapse and acute manic events

47

toxicity of lithium

LMNOP movement (tremor) nephrogenic DI hypOthyroidism Pregnancy problems

48

MOA buspirone

stimulates 5HT1a receptors

49

uses of buspirone

anxiolysis for GAD

50

benefits of buspirone

doesnt cause sedation or addiction doens't interfere with alcohol

51

examples of ssri's

fluoxetine sertraline paroxetine citalopram

52

clincical uses for ssri

OCD endogenous depression eating d/o

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examples of tricyclic antidepressants

imipramine amitriptyline desipramine nortiptyline clomipramine doxepin

54

MOA TCA

blocks reuptake of NorE and 5HT

55

uses for TCAs

major depression bedwetting (imipramine) OCD (clomipramine)

56

which TCA is used for bedwetting

imipramine

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which TCA is used for OCD

clomipramine

58

examples of heterocyclic anti-depressants

you need BUtane in your VEINs to MURder for a MAP of alcaTRAZ buproprion venlafaxine mirtazapine maportiline trazodone

59

examples of MAOIs

phenelzine tranylcypromine