Pharm4 - Pharm4

Question 1

MOA amphetamine

Answer 1

indirect general sympathetic agonist releases stored catecholamines

Question 2

MOA epehderine

Answer 2

indirect and direct sympathomimetic stimulates release of NE from sympathetic neurons

Question 3

MOA cocaine

Answer 3

blocks reuptake of NorE and DA

Question 4

MOA clonidine

Answer 4

centrally acting alpha agonist decreased central adregnergic outflow

Question 5

uses for epi

Answer 5

anaphylaxis glaucoma asthma hypotension

Question 6

uses for norE

Answer 6

hypotension (but decreases renal perfusion)

Question 7

uses for isoproterenol

Answer 7

rare… AV block

Question 8

uses for DA

Answer 8

shock (increases renal perfusion) heart failure

Question 9

uses for dobutamine

Answer 9

shock heart failure cardiac stress testing

Question 10

uses for amphetamines

Answer 10

narcolepsy obesity ADD

Question 11

uses for ephedrine

Answer 11

nasal decongestion urinary incontinence hypotension

Question 12

uses for phenylephrine

Answer 12

pupil dilator vasoconstriction nasal decongestion

Question 13

uses for albuterol

Answer 13

asthma

Question 14

uses for terbutaline

Answer 14

asthma

Question 15

uses for cocaine

Answer 15

vasoconstriction local anesthetic

Question 16

uses for clonidine

Answer 16

HTN (esp with renal dz b/c it doesn’t decrease blood flow to kidney)

Question 17

examples of inhaled anesthetics

Answer 17

halothane enflurane isoflurane (-ane)

Question 18

MOA inhaled anesthetics

Answer 18

unknown

Question 19

effects of inhaled anesthetics

Answer 19

myocardial depression respiratory depression n/v increased cerebral blood flow decreased cerebral demand

Question 20

toxicity of halothane

Answer 20

hepatotoxicity

Question 21

toxicity of methoxyflurane

Answer 21

nephrotoxicity

Question 22

toxicity of enflurane

Answer 22

pro-convulsant

Question 23

toxicity of any inhaled anesthetic

Answer 23

malignant hyperthermia (rare)

Question 24

types of drugs used as IV anesthetics

Answer 24

BB King on optiates proposes foolishly Barbiturates benzos Ketamine (arylclohxamines) opiates Propofol

Question 25

which barbiturate is commonly used as an IV anesthetic?

Answer 25

thiopental

Question 26

uses of thiopental

Answer 26

induction of anesthesia short surgical procedures

Question 27

which is the most common anesthetic used for endoscopy? what is it administered with?

Answer 27

midazolam gaseous anesthetics and narcotics

Question 28

side effects of midazolam

Answer 28

post-op respiratory depression hypotension amnesia

Question 29

how is the respiratory depression from midazolam treated?

Answer 29

flumezanil

Question 30

side effects of arylcyclohexamines

Answer 30

bad dreams CV stimulation disorientation hallucinations increased cerebral blood flow

Question 31

benefit of propofol

Answer 31

less post-op nausea than thiopental

Question 32

what is combined with opiates during general anesthesia?

Answer 32

other CNS depressants

Question 33

MOA local anesthetics

Answer 33

block Na channels by binding to specific receptors in inner portion of channel

Question 34

examples of atypical antipsychotics

Answer 34

olanzapine clozapine risperidone

Question 35

examples of typical antipsychotics

Answer 35

thioridazine haloperidol fluphenazine chlorpromazine

Question 36

MOA typical antipsychotics

Answer 36

block D2 receptor

Question 37

MOA atypical antipsychotics

Answer 37

blocks dopamine and 5HT receptors

Question 38

clinical uses of typical antipsychotics

Answer 38

schizophrenia psychosis acute mania Tourette's

Question 39

clinical uses for atypical antipsychotics

Answer 39

schizophrenia (+ and - sx)

Question 40

clinical uses for olanzapine

Answer 40

OCD anxiety d/o depression mania Tourette

Question 41

toxicity associated with typical antipsychotics

Answer 41

EPS endocrine effects anti-muscarinic effects (dry mouth) hypotension (from blocking alpha receptors), sedation (from blocking histamine receptors) NMS tardive dyskinesia

Question 42

what is tardive dyskinesia

Answer 42

stereotypical oral-facial movements d/t blocking DA receptors

Question 43

what is NMS

Answer 43

rigidity myoglobinuria autonomic instability hyperpyrexia

Question 44

tx of NMS

Answer 44

dantrolene and DA agonists

Question 45

toxicity associated wiht atypical antipsychotics

Answer 45

less EPS and anti-cholinergic effects Clozapine --> agranulocytosis

Question 46

uses for lithium

Answer 46

bipolar blocks relapse and acute manic events

Question 47

toxicity of lithium

Answer 47

LMNOP movement (tremor) nephrogenic DI hypOthyroidism Pregnancy problems

Question 48

MOA buspirone

Answer 48

stimulates 5HT1a receptors

Question 49

uses of buspirone

Answer 49

anxiolysis for GAD

Question 50

benefits of buspirone

Answer 50

doesnt cause sedation or addiction doens't interfere with alcohol

Question 51

examples of ssri's

Answer 51

fluoxetine sertraline paroxetine citalopram

Question 52

clincical uses for ssri

Answer 52

OCD endogenous depression eating d/o

Question 53

examples of tricyclic antidepressants

Answer 53

imipramine amitriptyline desipramine nortiptyline clomipramine doxepin

Question 54

MOA TCA

Answer 54

blocks reuptake of NorE and 5HT

Question 55

uses for TCAs

Answer 55

major depression bedwetting (imipramine) OCD (clomipramine)

Question 56

which TCA is used for bedwetting

Answer 56

imipramine

Question 57

which TCA is used for OCD

Answer 57

clomipramine

Question 58

examples of heterocyclic anti-depressants

Answer 58

you need BUtane in your VEINs to MURder for a MAP of alcaTRAZ buproprion venlafaxine mirtazapine maportiline trazodone

Question 59

examples of MAOIs

Answer 59

phenelzine tranylcypromine