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Flashcards in Pharm6 - Pharm6 Deck (58)
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1

how is NorE going to affect BP? HR?

A>B so.... systolic will increase diastolic will increase HR decreases (reflex brady)

2

how is epi going to affect BP? HR?

nonselective so... systolic will increase being controlled by a1 diastolic will decrease, being controlled by beta HR will increase (b1)

3

how does isoproterenol affect BP? HR?

B1=B2 so... systolic decreases diastolic decreaes HR increases (reflex tachy)

4

what will happen to BP if you administer an alpha blockade after giving epi?

it will decrease and then increase slightly net depressor effect b/c b2 takes over --> vasodilatioN

5

what will happen to BP if you administer an alpha blockade after giving phenylephrine?

A1>a2 there is no depressor effect seen in this situation b/c phenylephrine is a pure alpha agonist

6

what toxicities are seeen after giving 1st dose of an al blocker?

orthostatic hypotension ha dizziness

7

what toxicities are seen aftter giving phenoxybenzamine

orthostatic hypotension reflex tachy

8

what drugs are used to treat pheo?

phenoxybenzamine (irreversible alpha blocker) phentolamine (reversible alpha blocker)

9

which drugs are 1st generation H1 blockers?

diphenhydramine dimenhydrinate chlorpheniramine

10

which drugs are 2nd generation H1 blockers?

loratadin e fexofenadine desloratadine

11

what are 1st generation H1 blockers used for?

allergy motion sickness sleep aid

12

what are the 2nd gen H1 blockers used for?

allergy

13

toxicity of 1st gen H1 blockers?

sedation anti-muscarinic anti-alpha-adrenergic

14

toxicity of 2nd gen H1 blockers

less sedating than 1st generation

15

what are the different classes of drugs that treat asthma?

nonspecific beta agonists b2 agonists methylxanthines muscaranic antagonists cromalyn corticosteroids antileukotrienes

16

MOA isoproterenol

B1=B2 so, innervates bronchial smooth muscle and causes bronchodilation

17

MOA albuterol

B2 agonist, --> bronchodilation

18

MOA salmeterol

b2 agonist --> bronchodilation

19

when is albuterol used?

during acute exacerbation of asthma

20

when is salmeterol used?

for asthma proph

21

MOA theophylline

bronchodilation by inhibiting phosphodiesterase, decreasing cAMP hydrolysis inhibits effects of adenosine on bronchial smooth muscle (prevents bronchoconstriction)

22

adverse effects of salmeterol

tremor and arrhythmia

23

toxicity of theophylline

cardio and neurotoxicity

24

MOA ipratropium

muscarinic antagonist competitively blocks muscarinic receptors, preventing bronchoconstriction

25

MOA cromolyn

prevents release of mediators from mast cells

26

when is cromolyn used

asthma proph, ineffective during acute asthma attack

27

MOA beclomethasone

inhibits synth of all cytokines prevents formation of arachidonic acid by blocking phospholipase A2 inactivates NF-KB (transcription factor for TNF-alpha)

28

when are corticosteroids used in asthma treatment

1st line tx for chronic asthma

29

examples of anti-leukotrienes?

zileuton zafirlukast montelukast

30

MOA zileuton

5-lipoxygenase inhibitor blocks conversion of arachidonic acid to LT