Flashcards in Pharm6 - Pharm6 Deck (58)
how is NorE going to affect BP? HR?
A>B so.... systolic will increase diastolic will increase HR decreases (reflex brady)
how is epi going to affect BP? HR?
nonselective so... systolic will increase being controlled by a1 diastolic will decrease, being controlled by beta HR will increase (b1)
how does isoproterenol affect BP? HR?
B1=B2 so... systolic decreases diastolic decreaes HR increases (reflex tachy)
what will happen to BP if you administer an alpha blockade after giving epi?
it will decrease and then increase slightly net depressor effect b/c b2 takes over --> vasodilatioN
what will happen to BP if you administer an alpha blockade after giving phenylephrine?
A1>a2 there is no depressor effect seen in this situation b/c phenylephrine is a pure alpha agonist
what toxicities are seeen after giving 1st dose of an al blocker?
orthostatic hypotension ha dizziness
what toxicities are seen aftter giving phenoxybenzamine
orthostatic hypotension reflex tachy
what drugs are used to treat pheo?
phenoxybenzamine (irreversible alpha blocker) phentolamine (reversible alpha blocker)
which drugs are 1st generation H1 blockers?
diphenhydramine dimenhydrinate chlorpheniramine
which drugs are 2nd generation H1 blockers?
loratadin e fexofenadine desloratadine
what are 1st generation H1 blockers used for?
allergy motion sickness sleep aid
what are the 2nd gen H1 blockers used for?
toxicity of 1st gen H1 blockers?
sedation anti-muscarinic anti-alpha-adrenergic
toxicity of 2nd gen H1 blockers
less sedating than 1st generation
what are the different classes of drugs that treat asthma?
nonspecific beta agonists b2 agonists methylxanthines muscaranic antagonists cromalyn corticosteroids antileukotrienes
B1=B2 so, innervates bronchial smooth muscle and causes bronchodilation
B2 agonist, --> bronchodilation
b2 agonist --> bronchodilation
when is albuterol used?
during acute exacerbation of asthma
when is salmeterol used?
for asthma proph
bronchodilation by inhibiting phosphodiesterase, decreasing cAMP hydrolysis inhibits effects of adenosine on bronchial smooth muscle (prevents bronchoconstriction)
adverse effects of salmeterol
tremor and arrhythmia
toxicity of theophylline
cardio and neurotoxicity
muscarinic antagonist competitively blocks muscarinic receptors, preventing bronchoconstriction
prevents release of mediators from mast cells
when is cromolyn used
asthma proph, ineffective during acute asthma attack
inhibits synth of all cytokines prevents formation of arachidonic acid by blocking phospholipase A2 inactivates NF-KB (transcription factor for TNF-alpha)
when are corticosteroids used in asthma treatment
1st line tx for chronic asthma
examples of anti-leukotrienes?
zileuton zafirlukast montelukast