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Medicine 2 Week 6 - 11 > Pharmacogenetics > Flashcards

Flashcards in Pharmacogenetics Deck (9)
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1
Q

Reasons why patients might respond differently to medicines

A
Disease
Interactions
Renal/Liver Function
Age
Resistances
Genetics
Ethnicity

***DO NOT MEMORISE AT ALL

2
Q

Polymorphisms

A

Discontinuous genetic variation resulting in the occurrence of genes/bases

  • Single Nucleotide Polymorphism
    • Mutations leading to aa substitutions
3
Q

Activation and Deactivation Drugs

A

Deactivation - Drugs to inactivate metabolite

Activation - Pro-drug to activate metabolite

4
Q

Codeine on those with Chinese ethnicity

A

Chinese patients are more likely to be unable to metabolise codeine into its active form morphine since the drug requires metabolic conversion - patients do not benefit

5
Q

Effects of metabolism on Tamoxifen

A

It is a drug to treat lower oestrogen levels (I think)

In poor metabolisers, impaired conversion to active agonist may be noticed and the drug does not do much

6
Q

Resistance to Clopidogrel

A

Patients with heterozygous variant may need higher dose while those of homozygous of certain allele entirely do not respond

Anti-platelet med

7
Q

Risk of clopidogrel’s poor metabolism

A

It is used in stenting to prevent the formation of a thrombus, so if it is ineffective, a thrombus is more likely to form

8
Q

Why is warfarin dosage so individual to the patient

A

There are two competing genetic variations/polymorphisms so clearance is so significantly affected that it cannot be easily standardised

9
Q

DONT WORRY ABOUT THIS LECTURE, ITS MORE IMPORTANT TO BE VAGUELY AWARE OF THE CONTENT THAN TO ACTUALLY DEEP THE CONTENT

A

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