Review of Immune System/Autoimmune Diseases (REVISE) Flashcards Preview

Medicine 2 Week 6 - 11 > Review of Immune System/Autoimmune Diseases (REVISE) > Flashcards

Flashcards in Review of Immune System/Autoimmune Diseases (REVISE) Deck (10)
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1
Q

Antigens targeted in Lupus

A

Double stranded DNA

2
Q

Cells targeted in Type I Diaebete’s

A

Islet Cells

3
Q

Antigens targeted in Myasthenia Gravis

A

ACh Receptors

4
Q

Antigens targeted in Multiple Sclerosis

A

Myelin Sheath of Nerve Fibres

5
Q

What does a B cell bind to and what does a T cell bind to

A
6
Q

How is there such a variety of antibodies even though we only have a total of 22,000 genes

A

Our genome has many gene segments that encode for antibodies which rearrange and recombine to form a massive array of different antibodies on lymphocytes

7
Q

Why does autoimmunity occur

A

We physiologically always develop lymphocytes that recognise ‘self’ cells

There is an issue with the regulation of this self recognition that causes autoimmunity

8
Q

Self Tolerance

A

The ability of the immune system to recognize - and therefore not respond against - self-produced antigens

9
Q

Describe Central Tolerance

A

The process of eliminating any developing T or B lymphocytes that are reactive to self

REVISE

10
Q

ADD TO REST OF LECTURE

A

Decks in Medicine 2 Week 6 - 11 Class (54):