pharmacogenetics

Question 1

does everyone respond the same way to drugs

Answer 1

no

Question 2

pharmacogenetics

Answer 2

study of genetic basis for variation in drug response. looks at single gene interactions with drugs

Question 3

pharacogenomics

Answer 3

whole genome application of pharmacogenetics

Question 4

genotype

Answer 4

inherited genetic information

Question 5

phenotype

Answer 5

expression of genetic information related to morphology, functionality and behavior

Question 6

single nucleotide polymorphism

Answer 6

single base change in DNA coding for gene

Question 7

aldehyde dehydrogenase rola and insufficient consequese

Answer 7

ethanol is metabolized to acetaldehyde , builds up causes flushing, nausea

Question 8

insertion/deletions (indels)

Answer 8

addition/deletion of base in DNA strand in a specific gene

Question 9

N-acetyltransferase Type 2 (NAT2) does what

Answer 9

acetylates isoniazid

Question 10

what happens when you have low N-acetyltransferase Type 2 (NAT2)

Answer 10

acetylators have more isoniazid toxicity

Question 11

N-acetyltransferase Type 2 (NAT2) is seen in what population and not seen in what population

Answer 11

seen in: Inuit and Japanese

not seen in: Scandinavians, Jews, North African whites

Question 12

pharmacokinetic

Answer 12

what body does to drug
biotransformation
trapnsort (kidney, liver)

Question 13

pharmacodynamic

Answer 13

drug receptors and targets

Question 14

polymorphisms related to an underlying disease can impact response to what

Answer 14

unrelated drug therapy

Question 15

CYP3A5*1 wild type allele is common in what popluations

Answer 15

African > caucasaian

Question 16

drugs metabolized by CYP3A5 will be metabolized faster by which population

Answer 16

Africans

Question 17

Warfin pharmacology can be altered in drug process

Answer 17

metabolic enzyme

its target

Question 18

what does Warfarin do

Answer 18

blood thinner

Question 19

drug effect of 2B6 (CYP polymorphisms)

Answer 19

cyclophosphamide failure

Question 20

drug effect of 2C9 (CYP polymorphisms)

Answer 20

increased risk of bleeding - warfarin

Question 21

drug effect on GST (phase II enzyme polymorphism)

Answer 21

• increase toxicity of alkylating agents

- decrease response in breast cancer, AML

Question 22

Gilberts Syndrome 1A1 (phase II enzyme polymorphism) drug effect

Answer 22

• increase Irinotecan toxicity

- increase morphine plasma levels

Question 23

transporters of drugs are important where

Answer 23

biliary and renal excretion
choroid plexus
influx/efflux of drugs in excretory cells

Question 24

what does P-glycoprotein do

Answer 24

takes toxins out of drug

Digoxin

Question 25

Warfarin effects what enzyme/receptor

Answer 25

Vitamin K oxidoreductase

Question 26

G6PD gene produce deficiency uses what drug and what response

Answer 26

Dapsone

methemoglobinemia