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Flashcards in Pharmacology Deck (15):
1

How do monamine oxidase inhibitors work? Give an example of one

Slow down breakdown of neurotransmitters by inhibiting MAO enzyme
Phenelzine

2

List some TCA's

Amitriptyline
Clomipramine
Imipramine
Dosulepin

3

List some SSRI's

Fluoxetine
Paroxetine
Citalopram
Sertraline

4

Whereabouts in the synapse do MAO inhibitors act?

Presynaptic terminal

5

Whereabouts in the synapse do TCA's act?

Synaptic cleft

6

Whereabouts in the synapse do SSRI's act?

Presynaptic terminal

7

Which SSRI's can inhibit CYP450 system?

Fluoxetine
Paroxetine

8

List some adverse effects of SSRI's

Sexual dysfunction
GI disturbance
Short-term anxiety

9

List some adverse effects of TCA's

Constipation
Dry mouth
Blurred vision
Postural hypotension

10

Which class of drug are major tranquilizers - antipsychotics or benzodiazepines?

Antipsychotics

11

What is the general overall mechanism of benzodiazepines?

Act at GABA receptor mediate its inhibitory effect

12

List the pharmacological clinical effects of benzodiazepines

Reduce anxiety and aggression
Hypnosis, sedation
Muscle relaxation
Anticonvulsant effect

13

Which BZD acts as a GABA receptor antagonist and what is its effect on anxiety?

Flumazenil
Increases anxiety

14

Some people can develop tolerance to BZD's - what is the significance of this?

The doses that work for them can be lethal in normal people

15

List the clinical effects of rapid withdrawal of BZD's

Confusion, psychosis
Insomnia
Anxiety
Appetite + weight loss