Pharmacology & Medical Prescriptions Flashcards
Reviews basic pharmacology, drug classifications, prescription abbreviations, and medication administration terminology. (198 cards)
Define:
Pharmacokinetics
The branch of pharmacology concerned with the movement of drugs within the body, including absorption, distribution, metabolism, and excretion.
Understanding pharmacokinetics is essential for determining the appropriate dosing regimen for patients.
Define:
Pharmacodynamics
The study of the effects of drugs on biological systems and their mechanisms of action.
The pharmacodynamics of a medication explains why it can relieve pain effectively.
Define:
Absorption
The process by which a drug enters the bloodstream from the site of administration.
The absorption of the medication was rapid due to its intravenous administration.
Define:
Distribution
The dispersion or dissemination of substances throughout the fluids and tissues of the body.
After administration, the distribution of the drug was monitored to ensure it reached the target tissues.
Define:
Metabolism
The biochemical process that modifies drugs into more water-soluble compounds for easier excretion from the body.
The liver is primarily responsible for the metabolism of many medications.
Define:
Excretion
The process of eliminating waste products and drugs from the body, primarily through urine or feces.
Excretion of the drug occurs mainly through the kidneys.
Define:
Bioavailability
The proportion of a drug that enters the circulation when introduced into the body and is available for therapeutic effect.
The bioavailability of the oral medication was lower than expected due to first-pass metabolism.
Define:
Half-life
The time required for the concentration of a drug in the bloodstream to reduce to half its initial value.
The half-life of the drug is critical for determining dosing intervals.
Define:
Steady-state
A pharmacokinetic condition where the overall intake of a drug is equal to its elimination, resulting in a stable concentration in the bloodstream.
Reaching steady-state is important for maintaining therapeutic levels of the medication.
Define:
Therapeutic index
The ratio between the toxic dose and the therapeutic dose of a drug, indicating its safety margin.
A high therapeutic index suggests that the drug is safer for use in patients.
Define:
Loading dose
A higher initial dose of a drug given to rapidly achieve therapeutic levels in the bloodstream.
The physician prescribed a loading dose to quickly manage the patient’s symptoms.
Define:
Maintenance dose
The dose of a drug that maintains therapeutic drug levels after achieving the desired effect with a loading dose.
Following the loading dose, the patient will receive a maintenance dose to sustain the effect.
Define:
Dose-response curve
A graph that illustrates the relationship between the dose of a drug and the magnitude of its effect.
The dose-response curve helps in determining the optimal drug dosage for efficacy.
Define:
Potency
A measure of the amount of a drug needed to produce a specific effect; higher potency means less drug is required.
The potency of the new analgesic was significantly higher than that of its predecessor.
Define:
Efficacy
The ability of a drug to produce a desired therapeutic effect at its maximum dose.
The efficacy of the treatment was evaluated in clinical trials.
Define:
Affinity
The degree to which a drug binds to its receptor, influencing its potency and efficacy.
A drug with high affinity for its receptor will exert effects at lower concentrations.
Define:
Agonist
A substance that binds to a receptor and activates it to produce a biological response.
The drug acts as an agonist, stimulating the receptor to enhance its effects.
Define:
Antagonist
A substance that binds to a receptor but does not activate it, blocking or dampening the biological response.
The antagonist prevented the agonist from exerting its effect on the receptor.
Define:
Partial agonist
A substance that binds to a receptor and activates it but produces a weaker response than a full agonist.
The drug functions as a partial agonist, providing some relief without full activation.
Define:
Inverse agonist
A substance that binds to a receptor and induces a pharmacological response opposite to that of an agonist.
The inverse agonist reduced the activity of the receptor below its baseline level.
Define:
Receptor
A protein molecule that receives and transmits signals from drugs or hormones, initiating a biological response.
The drug binds to the receptor, triggering a cascade of cellular events.
Define:
Enzyme inhibition
The process by which a substance decreases the activity of an enzyme, affecting the metabolism of drugs.
Enzyme inhibition can lead to increased drug levels and potential toxicity.
Define:
Enzyme induction
The process by which a substance increases the activity of an enzyme, often leading to decreased drug levels.
Enzyme induction can reduce the effectiveness of certain medications.
Define:
First-pass effect
The metabolism of a drug before it reaches systemic circulation, often reducing its bioavailability.
The first-pass effect significantly impacted the oral bioavailability of the medication.