Flashcards in Phys Deck (75)
What is the nemonic for CARDIAC TISSUE CONDUCTION VELOCITY?
Park At VENTure AVenue (Purkinje->Atrial Muscle->Ventricular Muscle->AV node
WHEELHOUSE: which cytokine is produced EXLUSIVELY by lymphocytes??
IL-1 is primarily produced by mononuclear ________
macrophages (so i shouldn't look for it in HGF's??lol)
TNF-a is a cytokine primarily produced by activated _______
_______ is a cytokine chiefly generated by monocytes, macrophages, B cells, and NK cells and has numberous ANTIVIRAL functions
OOOO you should look for this primer with your HGF's!! ____ is a cytokine secreted by macrophages, T-cells, NK cells, mast cells, endothelial cells, and FIBROBLASTS and stimularws production of granulocytes and monocytes...
GM-CSF (granulocyte-macrophage colony-stimulating factor)
Desmosomes rely on ________ vs hemidesmosomes rely on _______ for connections
desmosomes = cadherins...hemidesmosomes = integrins
Bullous phemphigoid is associated with ________ whereas Pemphagus vulgaris is associated with ______
Phospholipase C (PLC) activation is a step in the _______ second messenger system
inositol triphosphate (IP3)
What is the immediate step in tyrosine kinase signaling activity?
DIMERIZATION after the ligand binds to the receptor
Disorders of Sexual Development: X-linked mutation of androgen receptor, breast development, absent uterus/upper vagina/cryptorchid testes, absent pubic heair, karyotype 46, XY
COMPLETE ANDROGEN INSENSITIVITY SYNDROME (testosterone receptors thoughout the body are nonfxn)
Disorders of Sexual Development: Hypoplastic or absent mullarian ductal system, breast development, absent or rudementary uterus/upper vagina/normal overies, normal pubic hair, karyotype 46, XX
Disorders of Sexual Development: Malformation of urogenital sinus and Mullarian ducts, breast development, normal uterus, abnormal vagina, normal overies, normal pubic hair, karyotype 46, XX
Transverse Vaginal Septum
Disorders of Sexual Development: Complete/partial absense of 1 X chromosome, variable breast dev, normal uterus/vagina/streak overies, normal pubic hair, karyotype 45,X
Which type of pneumocyte makes up 97% of alveolar surfaces?
Type I pneumocyte
Which type of pneumocyte secretes pulmonary surfactant?
Type II pneumocyte
What is the difference between Adult Hemogobin and Fetal Hemoglobin
Adult = 2 alpha and 2 beta chains...Fetal = 2 alpha 2 gamma
Hemoglobin Barts is incompatable with life because the fetus is missing what components?
The fetus is missing BOTH alpha chain genes and therefore cannot release oxygen
Which cells are responsible for making ABP (androgen-binding protein)? What hormone stimulates them?
What cells secrete testosterone?
Glucagon binds to G protein-coupled receptors on hepatocytes, avictating ___, which in turn stimulates _______ to increase intracellular _______ levels
Gs...adenylate cyclase...cyclic AMP (cAMP)
cAMP activates _______ which leads to the activation of key enzymes in glycogenolysis, and gluconeogenesis
protein kinase A
Huh, interesting...what nerve would you electrocoagulate to stop excessive axillary sweating?
thoracic SYMPATHETIC trunk at the T2 segment
Michaelis-Menten kinetics: an INCREASE in the amount of ENZYME available in a system will cause an INCREASE in _____, but NO CHANGE in ___
increase in Vmax, no change in Km
Lineweaver-Burke: A reversible competitiive inhibitor- ____ of the enzyme INCREASES, while ____ remains UNCHANGED
Lineweaver-Burke: non competitive inhibitor- ____ DECREASES, ____ remains the same
Lineweaver-Burke: UNcompetitive inhibitor (can only bin to enzyme-substrate complex), ___ and ____ DECREASE, with NO CHANGE in the slope and therefore a Parallel line with a higher Y intercept
Km and Vmax
Which pathway does PROTHROMBIN TIME measure?
EXTRINSIC pathway (VII)
_____ kinases promote the synthesis and phosphorylation of transcription factors that control the entry of cells into the cell division cycle.
MAP kinase (mitogen-activated protein)