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PHM 602- Diabetes > Pivotal Trials > Flashcards

Flashcards in Pivotal Trials Deck (15)
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1
Q

DCCT purpose

A

evaluated effects of intensive insulin treatment in T1DM

2
Q

Outcomes of DCCT

A

Intensive therapy reduces microvascular complications

The lower you keep A1C, the lower the risk for developing microvascular complications

3
Q

DDCT CV outcomes

A

Weren’t recognized until 10 years out

4
Q

UKPDS purpose

A

determine whether improved glucose control of T2DM would prevent clinical complications

5
Q

UKPDS outcomes

A

To reduce complications of DM, it’s necessary to control BG, A1C, BP

Every percentage point reduction in A1C lead to a decrease in microvascular complications, DM-related death, and MI

6
Q

UKPDS intensive therapy outcomes

A

decreased DM-related death, MI, death from any cause

7
Q

ACCORD purpose

A

determine whether improved glucose control in T2DM will prevent clinical complications (same as UKPDS!)

8
Q

ACCORD outcomes

A

Intensive glucose treatment strategy was associated with a higher risk of death

9
Q

A higher risk of death from the ACCORD trial was associated with these 3 factors:

A
  1. A1C ≥8.5%
  2. Hx of neuropathy
  3. Hx of ASA use
10
Q

ADVANCE purpose

A

evaluate whether or not micro and macrovascular events would decrease in an intensive treatment group in patients with T2DM

11
Q

ADVANCE outcomes

A

Decrease in micro and macrovascular complications with intensive therapy

12
Q

VADT purpose

A

evaluate intensive glucose control and its effect on complications in T2DM

13
Q

VADT outcomes

A

lower threshold to start insulin decreased major MACROvascular complications

severe hypoglycemia in the last 90 days was a strong predictor of mortality

14
Q

CVD outcome for DDP4is

A

no effect on CVD outcomes

15
Q

CVD outcome for SGLT2is and GLP-1RAs

A

provide CV protection/benefit