Thiazolidinediones (TZD) DI Flashcards Preview

PHM 602- Diabetes > Thiazolidinediones (TZD) DI > Flashcards

Flashcards in Thiazolidinediones (TZD) DI Deck (19)
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1
Q

TZDs primary MoA

A

Increase peripheral muscle glucose sensitivity

2
Q

TZDs secondary MoA

A

Decrease glucose output from liver

3
Q

TZD drugs

A

Pioglitazone (Actos), rosiglitazone (Avandia)

4
Q

Brand name of pioglitazone

A

Actos

5
Q

Brand name of rosiglitazone

A

Avandia

6
Q

Pioglitazone dosing

A

15-30mg PO QD, MDD 45mg

7
Q

Rosiglitazone dosing

A

4-8mg PO QD, MDD 8mg

8
Q

Side effects of TZDs

A

edema, weight gain, hepatotoxicity

9
Q

Pioglitazone specific side effects

A

Bladder cancer and fractures

10
Q

BBW for rosiglitazone

A

CHF and MI

11
Q

TZD CIs

A

NYHA Class III-IV, symptomatic CHF, ACS, active bladder cancer

12
Q

Precautions of TZDs

A

NYHA Class I-II, women, MI for rosiglitazone

13
Q

Counseling points for TZDs

A

Take once daily at the same time each day, ask about weight gain

14
Q

TZD pearls

A

Lowers A1C by 1%, pioglitazone has potential ASCVD benefit but both increase HF risk, neutral on CKD.

15
Q

Renal dosing for TZD

A

Not required

16
Q

TZD monitoring

A

FBG/PPG, A1C, LFTs, edema, weight gain, cholesterol panel

17
Q

TZD peak effect

A

6-8 weeks

18
Q

TZDs in ADA guidelines

A

used to minimize hypoglycemia or if cost is a major issue

19
Q

TZDs in AACE guidelines

A

not first-line