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Previous paper Qns Flashcards

1
Q

Name some drugs of BCS class III

A

Acyclovir, Atenolol, Captopril

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2
Q

What is meant by ‘Dwell time’ in the compression of tablets?

A

Time it takes for the punches to stop moving vertically and to achieve maximum penetration of the die under the primary compression rollers

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3
Q

Spin quantum number of ¹³C NMR is…

A

1/2

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4
Q

What is the starting material for the synthesis of Lignocaine?

A

2, 6 - Xylidine

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5
Q

Rancidity value is determined by…

A

Peroxide value

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6
Q

Bloom strength is directly proportional to…

A

Molecular weight

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7
Q

When is the best time to collect a medicinal bark?

A

After the leaf falls

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8
Q

Name a specific category of anti-biotics which undergo light catalyzed auto-oxidation

A

Polyene antibiotics

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9
Q

What type of rheological behaviour of fluid is ‘time independent’?

A

Anti-thixotropic

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10
Q

Name the diagnostic test for Syphillis

A

Kahn’s test

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11
Q

Diagnostic test for AIDS

A

ELISA

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12
Q

Equivalent weight of KMnO4 in acidic solution

A

31.6

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13
Q

Which zone is dry and hot?
Zone I
Zone II
Zone III
Zone IV

A

Zone III

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14
Q

What is the composition of Lindlar catalyst?

A

Palladium and CaCO3

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15
Q

Alfa Alfa belongs to which family?

A

Leguminosceae

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16
Q

Name an Anti-oxidant obtained from a desert plant, which shows synergistic action with citric acid

A

Nor de-hydro guaiaretic acid (NDGA)

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17
Q

Which volatile oil is heavier than H20?

A

Cinnamon oil

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18
Q

How many AA are present in H1 receptor protein?

A

487 AA

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19
Q

Name the ionisation technique most useful for large biomolecules like proteins

A

Electrospray Ionisation (ESI)

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20
Q

M.O.A of Metformin

A

It acts by increasing the levels of INCRETIN hormone by inhibiting the enzyme Di-peptidyl peptidase 4 (DPP-4)

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21
Q

The etiology of Jaundice could be HEMOLYTIC ANEMIA if….

A

Unconjugated bilirubin = Conjugated bilirubin

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22
Q

Biological activity of Synthetic Adrenaline = _________

A

25% (S - Adrenaline)

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23
Q

Murmurs are disorders involving the….

A

Pulmonary vein

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24
Q

Tetracycline undergoes epimerization at C4 in the pH 4-8 to give….

A

Iso-tetracycline

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25
What kind of a disease is Leprosy?
Fungal disease
26
Type III hypersensitivity is ________
Cell-mediated or delayed hypersensitivity
27
As per Brownsted Lowry theory, an acid is a...
Substance or molecule which donates a proton
28
Aerobic dehydrogenase in biological oxen. contains....
FMN or FAD
29
Plasma protein bound drugs are ____________ inert
Pharmacodynamically
30
What is the chemical name of SPIRIT OF SALT
HCl
31
Name a short acting Anti-ChE drug
Edrophonium
32
Who proposed the theory that, "In general anesthetics, chain length is directly proportional to lipid solubility and anesthetic potency"?
Mayer Overton
33
Which immunoglobulin can cross the placenta?
IgG
34
Which antibody is dominant in immune responses
IgM
35
Causative organism for Syphillis
Treponema palladum
36
What is the outer covering of Testes called?
Tunica vaginalis
37
What is the optimum temperature for the rapid growth of mesophils?
25 - 40°C
38
Name the most common neoplasm in people with AIDS
Kaposi sarcoma
39
Coomb's test is used for the detection of...
Anti-globulin
40
Which nerve is important for motor functions?
Accessory cranial nerve
41
What is Transduction?
Virus mediated transfer of host DNA from one cell to another
42
Name the best technique for detecting HIV
Reverse transcriptase PCR
43
What will the LOG P value of an ideal candidate for TRANSDERMAL PERMEATION be?
1-3
44
M.O.A of Artemesinin
They act by generating ROS by the cleavage of enderoperoxide bridge, leading to the death of the parasite
45
Which cranial nerve regulates heart beat?
Cranial nerve X
46
In the process of drying, Adiabatic saturation temperature is same as....
Wet bulb temperature
47
What would the product of a reaction involving p-ANISALDEHYDE and FORMALDEHYDE in the presence of conc.NaOH be?
p - Methoxy benzyl alcohol
48
Name the precursor in the synthesis of Cholesterol
Lanosterol
49
Naphthalene + CrO³ in the presence of glacial CH³COOH ---> ______________
Naphthalene - 1,4 - dione
50
Name the drug with the IUPAC name Ethyl - 2 - (p-chlorophenoxy) - 2 - methyl propionate
Clofibrate
51
What are the Vibrational modes shown by SO2 in IR
Symmetric and Asymmetric stretching
52
Establishing the structure of which biomolecule is more difficult than others?
Polysaccharide
53
Dipole-Dipole weak interactions are also called ________
Keeson forces
54
Which is the perfect orientation of Diel's Alder reaction between reactants?
Diene shoukd be S-cis and reaction should be 'endo' facing
55
Wavelength of absorption of 3-methyl naphthalene
240 nm
56
Lucas test is rapid with which degree of alcohol?
3°
57
Write the following soln in their DECREASING order of Dielectric constant: Formamide, Methanol, Acetone, Water
Formamide > Acetone > Methanol > H20
58
Which vitamin is a co-factor for Succinate dehydrogenase?
B2
59
Which vitamin is the electron acceptor in Isocitrate dehydrogenase?
B3
60
Which vitamin is a part of co-enzyme A?
B5
61
Which vitamin acts in the decarboxylation of alpha-keto glutarate dehydrogenase?
B1
62
Give some examples of Carbapenam
Thienamycin, Inipenam, Meropenam
63
When a strong electrolyte is diluted, what effect does it have on SPECIFIC CONDUCTANCE and EQ.CONDUCTANCE?
Sp. Conductance decreases Eq. Conductance increases
64
Which solution has the highest Dielectric constant at 25°C? Phenol, Ethanol, Glycerin, Acetone
Glycerin
65
Kozeny Carmen equation is for. . .
The surface area of powder
66
Name a surfactant which has a high HLB value
Tween 80
67
Which anti-biotic requires an acidic pH for treating UTI?
Carbenicillin
68
Name a drug with an apparant volume of distribution of 6500L
Chloroquine
69
Interfacial forces are related to contact angle in which equation?
Young's equation
70
Difference in velocity between 2 planes of liquid separated in distance is called...
Rate of shear
71
Suspensions containing >50% of small de-flocculated particles show which type of flow?
Dialatant
72
Common instruction for a mixture preparation in the absence of one provided by the prescriber
2 of 5mL spoonful, take 3 times a day
73
Re-arrange the intermediates in their right sequence for Opium alkaloids synthesis: Reticuline, Tyrosine, Morphine, Codeine, Thebaine
Tyrosine, Reticuline, Morphine, Thebaine, Codiene
74
Lycopodium spore method is used to determine _________
% purity of drugs
75
Which family does Isabgol belong to?
Plantaginaceae
76
Nicotinic acid acts via _______receptor
GPCR
77
Trasluzumab acts by...
Inhibiting EGFR and HER-2
78
Name some TNF alpha drugs.
Etanercept, Adalizumab, Infliximab
79
Name a drug which produces Mydriasis W/O cycloplegia.
Ephedrine
80
Tricyclic anti-depressants affect the function of which anti-hypertensive drug?
Chlonidine
81
Alzheimer's disease affects which part of the brain?
Hippocampus
82
Name a drug which can act as a male contraceptive w/o affecting libido or potency
Gossypol
83
Name an anti-cancer drug which can be taken orally and has 100% bioavalability
Hydroxyurea
84
P wave corresponds to _____________
Atrial depolarization
85
Which nerve is needed for 'Near vision'?
Oculomotor Cranial Nerve
86
Hemophilus Influenza Type B is a ______ type of vaccine
Conjugate
87
A very fine powder according to I.P and B.P...
In which all particles pass through 120 sieve
88
Name a metabolite used to inactivate vasicotoxic metabolites leading to hemorrhagic cystitis by alkylating agents
Mesna
89
Lateral Geniculate Nucleus is associated with which sensory function and what does it do?
It is associated with Vision and it acts as a relay station between Retina and Visual cortex

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