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MTAP 2 > Proteins > Flashcards

Proteins Flashcards

(71 cards)

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1
Q

Not readily demonstrated or visible in typical serum electrophoresis

A

Prealbumin (Transthyretin)

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2
Q

Found between the anode and albumin region

A

Prealbumin (Transthyretin)

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3
Q

Indicator of nutrition

A

Prealbumin (Transthyretin)

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4
Q

Binds thyroid hormones (T3, T4)

A

Prealbumin (Transthyretin)

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5
Q

Binds retinol-binding protein (Vit A)

A

Prealbumin (Transthyretin)

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6
Q

Binds bilirubin, steroids, fatty acids

A

Albumin

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7
Q

Major contributor to oncotic pressure

A

Albumin

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8
Q

Highest concentration in the plasma or serum

A

Albumin

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9
Q

Most abundant, Smallest and fastest migration

A

Albumin

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10
Q

Highest peak in electrophoresis

A

Albumin

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11
Q

Predominant protein present in the diet

A

Albumin

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12
Q

↓plasma volume ↑concentration

A

Albumin

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13
Q

α1-Globulin proteins

A

α1 - Antitrypsin
α1 - Fetoprotein
α1 - acid glycoprotein
α1 - Lipoprotein
α1 - Antichymotrypsin
Inter-α-trypsin inhibitor
Gc-globulin
Gc: group specific component

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14
Q

Protease inhibitor

A

α1 - Antitrypsin
α2-Macroglobulin

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15
Q

Principal fetal protein

A

a1-fetoprotein

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16
Q

a1-fetoprotein is INCREASED in:

A

spina bifida
neural tube defects
fetal distress

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17
Q

a1-fetoprotein is DECREASED in:

A

Down syndrome
Trisomy 18

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18
Q

In adults, used as tumor marker (malignancy hepatoma)
- Hepatocellular conditions in adults

A

a1-fetoprotein

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19
Q

Transport lipids from the tissues (HDL)

A

a1-lipoprotein

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20
Q

Inhibits serine proteinases

A

a1-antichymotrypsin
Inter-α-trypsin inhibitor

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21
Q

Transports Vitamin D and binds actin
- Vit. D is a cholecalciferol

A

Gc-globulin
Gc: group specific component

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22
Q

α2-Globulin proteins

A

Haptoglobin
Ceruloplasmin
α2 - Macroglobulin

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23
Q

Binds with free hemoglobin
- Hb released from RBC during hemolytic conditions (intravascular)

A

Haptoglobins

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24
Q

Decreased ceruloplasmin is seen in these conditions

A

Wilson’s dse
Menkes syn. (kinkey hair dse.)
Kayser Fleisher rings in cornea

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25
β-Globulin proteins
Pre-β-lipoprotein (VLDL) Transferrin Hemopexin β-Lipoprotein (LDL) β2-Microglobulin C4, C3, C1q complement Fibrinogen CRP
26
Transports lipids (endogenous tgl in the liver) (VLDL triglyceride)
Pre-β-lipoprotein (VLDL)
27
Found between the α2 and β region
Pre-β-lipoprotein (VLDL)
28
Transport Iron (bone marrow or liver)
Transferrin
29
Transferrin Inc: Dec:
↑ IDA: Decreased iron in the circulation ↓ Hemochromatosis: Excess iron in the circulation
30
Binds heme
Hemopexin
31
Transports lipids (dietary) (LDL cholesterol)
β-Lipoprotein (LDL)
32
Component of HLA molecules (Human Leukocyte Antigen)
β2-Microglobulin
33
Immune response • Named as Complement because their presence would enhance the activity of antibodies in eliminating pathogens
C4, C3, C1q complement
34
Precursor of fibrin clot Factor I Found in β region
Fibrinogen
35
Motivates phagocytosis in inflammation - Promotes migration of WBCs to the site of inflammation
CRP
36
First to increase during acute inflammation
CRP
37
Present in the B region when subjected to electrophoresis
CRP
38
produced in the liver by plasma cells) (nearest the cathode; farthest the anode) found in the gamma region when subjected to electrophoresis (negative charge)
γ-Gamma-Globulins
39
Antibodies predominantly found in the serum of healthy individuals
IgG
40
Predominant in the Secondary or the memory or the anamnestic response
IgG
41
Smallest Ab
IgG
42
Only antibody that can cross the placenta
IgG
43
Can provide neonatal immunity
IgG
44
Antibodies in the secretion Can provide mucosal immunity
IgA
45
Also present in the colostrum (breastmilk) along with IgG
IgA
46
Antibodies in early response
IgM
47
Predominant antibody in primary immune response
IgM
48
Biggest Ab
IgM
49
Antibodies (reagen, allergy)
IgE
50
Increased in parasitic infection (helminthic)
IgE
51
Reaginic Ab
IgE
52
Surface antibody • Not yet fully established in terms of the function
IgD
53
Oxygen carrier in muscles
Myoglobin
54
Cardiac Marker (AMI) • Earliest to increase in case of acute MI
Myoglobin
55
↑ 2-3 hours of onset, peak at 8-12 hours of MI
Myoglobin
56
↑ in crushing injury and muscle dystrophy
Myoglobin
57
Cardiac marker for acute coronary syndrome
Troponin
58
Neurohormones that affect body fluid homeostasis and blood pressure
BNP
59
Marker for congestive heart failure
BNP
60
• Cellular interaction (e.g. cell adhesion) • Adherence of the placenta to the uterus ▪ ↑ - Preterm labor and delivery
Fibronectin
61
Proteolytic fragment of collagen
Cross-Linked C-Telopeptides
62
Biochemical marker of bone resorption (destruction)
Cross-Linked C-Telopeptides
63
Synonym: Prostaglandin D synthase
β-Trace Protein
64
Marker for CSF leakage (e.g. head injuries)
β-Trace Protein
65
↑ Damage in blood brain barrier
β-Trace Protein
66
Cysteine proteinase inhibitor
Cystatin C
67
Serum marker for glomerular filtration rate (kidney function., for DM px)
Cystatin C
68
Fibrous protein aggregates formed from alteration of β pleated sheaths
Amyloid
69
Differential diagnosis of Alzheimer
Amyloid
70
Low Aβ42 with high Tau proteins
Amyloid
71
Acute phase reactants
a1-antitrypsin a1-acid glycoprotein haptoglobins ceruloplasmin hemopexin CRP

MTAP 2 (23 decks)

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