Psych Drugs Flashcards by elliot sultanik

Drug for alchohol withdrawal?

Benzodiazepines

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Drug for anxiety?

SSRI, SNRI, buspirone

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ADHD drug?

Methylphenidate, amphetamines

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Bipolar drugs?

Lithium; valproid acid; carbamazepine; atypical antipsychotics

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Bulimia drug?

SSRI

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Depression with insomnia?

Mirtazapine

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OCD?

SSRI and clomipramine

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Panic disorder drugs?

SSRI, Vanlafaxine, benzodiazepines

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PTSD drugs?

SSRI

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Tourette’s drugs?

antipsychotics (halo; risperidone)

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MOA of typical antipsychotics?

Block dopamine D2 receptors leading to an increase in cAMP

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Typical antipsychotics with extrapyramidal symptoms?

Trifluoperazine, fluphenazine, haloperidol (Try to Fly High)

High potency

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Low potency typical antipsychotics (anticholinergic; antihistamine; alpha 1 blockade)

Chlorpromazine, Thioridazine (Cheating Thieves are low)

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Patient presents with myoglobinuria; autonomic instability, hyperpyrexia, rigidity– What is this called? What is treatment?

Neuroleptic malignant syndrome– treate with dantrolene (muscle relaxant) and D2 agonists (bromocriptine)

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Side effects of typical antipsychotics?

Highly lipid soluble (removed slowly)
Extrapyramidal (eg dyskinesias)
Dopamine block (hyperprolactinemia)
Muscarininc and alpha 1 and histamine blockade

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Stereotypic oral facial movements as a result of long term antipsychotic use?

Tardive dyskinesia– usually irreversible

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Fever; encephalopathy; unstable vitals, rigidity of muscles, elevated enzymes?

Neuroleptic malignant syndrome (FEVER)

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Typical antipsychotics?

Haloperidol and “azines” (eg. fluphenazine, thioridazine, chlorpromazine, trifluoperazine)

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Atypical antipsychotics?

It’s Atypical for OLd CLOSets to QUIETly RISPER from A to Z (Olanzapine, clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)

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Least sedating atypical antipsychotic and why?

Aripiprazole because it’s a partial agonist and antagonist

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Atypical antipsychotic side effect of agranulocytosis?

Clozapine

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Side effect of clozapine?

Agranulocytosis– requires weekly WBC AND seizures

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Atypicals that cause weight gain?

Olanzapine and clozapine (If i gain weight, I can’t be on the OC)

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Atypical that prolongs QT interval?

Ziprasidone

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Uses of Lithium?

SIADH and bipolar

Side effects of lithium?

LMNOP: Movement (tremor), Nephrogenic diabetes insipidus hypOthyroidism Pregnancy problems Can also cause heart block

Blood work that must be checked in a patient on Lithium?

Thyroid levels

Fetal defects associated with lithium?

Cardiac defects include Ebstein anomaly and malformation of great vessels.

Lithium is excreted by?

Kidneys-- reabsorbed at proximal convoluted tubules following Na reabsorption

Stimulates 5HT1a-- used for GAD?

Buspirone-- takes 1-2 weeks to take effect

What should you tell a patient when starting them on Buspirone?

Takes 1-2 weeks to take effect

SSRIs are not used in which two diseases?

Schizophrenia and Bipolar

Methylphenidate?

CNS stimulant (ritalin) increases catacholamines at synaptic cleft-- especially NE and dopamine

Treatment of ADHD?

end in "amphetamine" and Methylphenidate

Work by increasing catecholamines at synaptic cleft?

CNS stimulants (amphetamines and methylphenidate)-- used for narcolepsy and appetite control

4 hr actue muscle spasm, stiffness

dystonia (EPS side effect of typicals)

4 day restlessness?

Akathisia (SE of typicals)

4 week parkinson like symptoms?

Bradykinesia (side effect of typicals)

Typicals that cause deposits in eye?

Chlorpromazine goes to cornea | Thioridazine goes to reTina

Deposits in retina?

thioridazine

Deposits in cornea?

Chlorpromazine

SSRIs?

Fluoxetine (Prozac); Paroxetine (Paxol); Sertraline (zoloft); Citalopram--- FLashbacks PARalyze SEnior CITizens

Fluoxetine?

SSRI

Paroxetine?

SSRI

Citalopram?

SSRI

Sertraline?

SSRI

Pt. presents with fever, confusion, twitching of muscles, flushing, and diarrhea after starting a medication for depression. How should this patient be treated?

Pt. presenting with Serotonin syndrome--- treat with cyproheptadine which is a seretonin antagonist

Cyproheptadine?

Seretonin antagonist used to treat serotonin syndrome

Venlafaxine?

SNRI-- inhibit serotonin and NE reuptake

Duloxetine?

SNRI-- inhibit serotonin and NE reuptake

SNRI also indicated for peripheral neuropathy?

Duloxetine

SNRI that has greater effect on NE?

Duloxetine

Most common side effect of SNRI (duloxetine and venlafaxine)

Increased blood pressure

All TCAs end in blank or blank?

iptyline or ipramine except doxepin and amoxapine (yes, I know this is bullshit, but remember it anyhow)

MOA of TCA?

block reuptake of NE and seretonin

Antidepressant indicated for fibromyalgia?

TCA (end in "iptyline" or "ipramine" except doxepin and amoxapine)

Pt. presents with postural hypotension after starting an antidpressent?

TCA have alpha 1 blocking effects which can cause postural hypotension

Pt. presents with urinary retention, dry mouth and fast heart rate after starting an antidepressant?

TCA-- have atropine like effects

Amitriptyline has greater blank side effects than nortriptyline?

anticholinergic

TCA with highest seizure threshold?

Desipramine

Pt. presents with convulsions and arrhythmias after starting an antidepressant? How do we treat?

TCA-- NaHCO3

TCA that should be used in elderly?

Nortriptyline due to lesser anticholinergic side effects

NaHCO3

Treatment for cardiovascular toxicity of TCA

MAO inhibitors?

(MAO Takes Pride In Shanghai) Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (MaO-B inhibitor)

Pt. is taking an antidepressant. He begins to go into cardiac arrest after a wine and cheese party?

MAO inhibitors (Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline-- hypertensive crisis with ingestion of tyramine

Antidepressant that should not be taken with St. Johns Wart, Meperidine, and Dextromethorphan?

MAO inhibitors Dextromethorphan and MAO can lead to seretonin syndrome

Used for smoking cessation?

Bupropion-- increased NE and dopamine via unknown mechanism

Atypical antidepressent that may cause insomnia and seizure in bulimic patients but has no sexual side effects?

Bupropion

Atypical antidepressant with alpha 2 antagonist activity and seretonin antagonist?

Mirtazapine-- increased appetite and weight gain which may be desirable in elderly or anorexic patients

atypical antidepressant that is used in elderly population due to weight gain and increase appetite?

mirtazapine

Maprotiline?

Blocks NE reuptake-- causes orthostatic hypotension

Atypical antidepressant that causes orthostatic hypotention?

Maprotiline-- blocks NE reuptake

Used primarily for insomnia?

Trazadone-- causes priapism and postural hypotension

Buprenorphine

Used for Opioid withdrawal (eg heroin)

Psych Drugs Flashcards

(74 cards)