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Flashcards in Psych Drugs Deck (74):
1

Drug for alchohol withdrawal?

Benzodiazepines

2

Drug for anxiety?

SSRI, SNRI, buspirone

3

ADHD drug?

Methylphenidate, amphetamines

4

Bipolar drugs?

Lithium; valproid acid; carbamazepine; atypical antipsychotics

5

Bulimia drug?

SSRI

6

Depression with insomnia?

Mirtazapine

7

OCD?

SSRI and clomipramine

8

Panic disorder drugs?

SSRI, Vanlafaxine, benzodiazepines

9

PTSD drugs?

SSRI

10

Tourette's drugs?

antipsychotics (halo; risperidone)

11

MOA of typical antipsychotics?

Block dopamine D2 receptors leading to an increase in cAMP

12

Typical antipsychotics with extrapyramidal symptoms?

Trifluoperazine, fluphenazine, haloperidol (Try to Fly High)

High potency

13

Low potency typical antipsychotics (anticholinergic; antihistamine; alpha 1 blockade)

Chlorpromazine, Thioridazine (Cheating Thieves are low)

14

Patient presents with myoglobinuria; autonomic instability, hyperpyrexia, rigidity-- What is this called? What is treatment?

Neuroleptic malignant syndrome-- treate with dantrolene (muscle relaxant) and D2 agonists (bromocriptine)

15

Side effects of typical antipsychotics?

Highly lipid soluble (removed slowly)
Extrapyramidal (eg dyskinesias)
Dopamine block (hyperprolactinemia)
Muscarininc and alpha 1 and histamine blockade

16

Stereotypic oral facial movements as a result of long term antipsychotic use?

Tardive dyskinesia-- usually irreversible

17

Fever; encephalopathy; unstable vitals, rigidity of muscles, elevated enzymes?

Neuroleptic malignant syndrome (FEVER)

18

Typical antipsychotics?

Haloperidol and "azines" (eg. fluphenazine, thioridazine, chlorpromazine, trifluoperazine)

19

Atypical antipsychotics?

It's Atypical for OLd CLOSets to QUIETly RISPER from A to Z (Olanzapine, clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)

20

Least sedating atypical antipsychotic and why?

Aripiprazole because it's a partial agonist and antagonist

21

Atypical antipsychotic side effect of agranulocytosis?

Clozapine

22

Side effect of clozapine?

Agranulocytosis-- requires weekly WBC AND seizures

23

Atypicals that cause weight gain?

Olanzapine and clozapine (If i gain weight, I can't be on the OC)

24

Atypical that prolongs QT interval?

Ziprasidone

25

Uses of Lithium?

SIADH and bipolar

26

Side effects of lithium?

LMNOP: Movement (tremor),
Nephrogenic diabetes insipidus
hypOthyroidism
Pregnancy problems

Can also cause heart block

27

Blood work that must be checked in a patient on Lithium?

Thyroid levels

28

Fetal defects associated with lithium?

Cardiac defects include Ebstein anomaly and malformation of great vessels.

29

Lithium is excreted by?

Kidneys-- reabsorbed at proximal convoluted tubules following Na reabsorption

30

Stimulates 5HT1a-- used for GAD?

Buspirone-- takes 1-2 weeks to take effect

31

What should you tell a patient when starting them on Buspirone?

Takes 1-2 weeks to take effect

32

SSRIs are not used in which two diseases?

Schizophrenia and Bipolar

33

Methylphenidate?

CNS stimulant (ritalin) increases catacholamines at synaptic cleft-- especially NE and dopamine

34

Treatment of ADHD?

end in "amphetamine" and Methylphenidate

35

Work by increasing catecholamines at synaptic cleft?

CNS stimulants (amphetamines and methylphenidate)-- used for narcolepsy and appetite control

36

4 hr actue muscle spasm, stiffness

dystonia (EPS side effect of typicals)

37

4 day restlessness?

Akathisia (SE of typicals)

38

4 week parkinson like symptoms?

Bradykinesia (side effect of typicals)

39

Typicals that cause deposits in eye?

Chlorpromazine goes to cornea
Thioridazine goes to reTina

40

Deposits in retina?

thioridazine

41

Deposits in cornea?

Chlorpromazine

42

SSRIs?

Fluoxetine (Prozac); Paroxetine (Paxol); Sertraline (zoloft); Citalopram--- FLashbacks PARalyze SEnior CITizens

43

Fluoxetine?

SSRI

44

Paroxetine?

SSRI

45

Citalopram?

SSRI

46

Sertraline?

SSRI

47

Pt. presents with fever, confusion, twitching of muscles, flushing, and diarrhea after starting a medication for depression. How should this patient be treated?

Pt. presenting with Serotonin syndrome--- treat with cyproheptadine which is a seretonin antagonist

48

Cyproheptadine?

Seretonin antagonist used to treat serotonin syndrome

49

Venlafaxine?

SNRI-- inhibit serotonin and NE reuptake

50

Duloxetine?

SNRI-- inhibit serotonin and NE reuptake

51

SNRI also indicated for peripheral neuropathy?

Duloxetine

52

SNRI that has greater effect on NE?

Duloxetine

53

Most common side effect of SNRI (duloxetine and venlafaxine)

Increased blood pressure

54

All TCAs end in blank or blank?

iptyline or ipramine except doxepin and amoxapine (yes, I know this is bullshit, but remember it anyhow)

55

MOA of TCA?

block reuptake of NE and seretonin

56

Antidepressant indicated for fibromyalgia?

TCA (end in "iptyline" or "ipramine" except doxepin and amoxapine)

57

Pt. presents with postural hypotension after starting an antidpressent?

TCA have alpha 1 blocking effects which can cause postural hypotension

58

Pt. presents with urinary retention, dry mouth and fast heart rate after starting an antidepressant?

TCA-- have atropine like effects

59

Amitriptyline has greater blank side effects than nortriptyline?

anticholinergic

60

TCA with highest seizure threshold?

Desipramine

61

Pt. presents with convulsions and arrhythmias after starting an antidepressant? How do we treat?

TCA-- NaHCO3

62

TCA that should be used in elderly?

Nortriptyline due to lesser anticholinergic side effects

63

NaHCO3

Treatment for cardiovascular toxicity of TCA

64

MAO inhibitors?

(MAO Takes Pride In Shanghai) Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (MaO-B inhibitor)

65

Pt. is taking an antidepressant. He begins to go into cardiac arrest after a wine and cheese party?

MAO inhibitors (Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline-- hypertensive crisis with ingestion of tyramine

66

Antidepressant that should not be taken with St. Johns Wart, Meperidine, and Dextromethorphan?

MAO inhibitors

Dextromethorphan and MAO can lead to seretonin syndrome

67

Used for smoking cessation?

Bupropion-- increased NE and dopamine via unknown mechanism

68

Atypical antidepressent that may cause insomnia and seizure in bulimic patients but has no sexual side effects?

Bupropion

69

Atypical antidepressant with alpha 2 antagonist activity and seretonin antagonist?

Mirtazapine-- increased appetite and weight gain which may be desirable in elderly or anorexic patients

70

atypical antidepressant that is used in elderly population due to weight gain and increase appetite?

mirtazapine

71

Maprotiline?

Blocks NE reuptake-- causes orthostatic hypotension

72

Atypical antidepressant that causes orthostatic hypotention?

Maprotiline-- blocks NE reuptake

73

Used primarily for insomnia?

Trazadone-- causes priapism and postural hypotension

74

Buprenorphine

Used for Opioid withdrawal (eg heroin)