Quiz 5 Flashcards

1
Q

The greater omentum connects ___ to ___. Whereas the lesser omentum connects ___ to ___.

A

Stomach (greater curvature) to transverse colon

Liver to stomach (lesser curvature)

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2
Q

Define the following organs… intraperitoneal, primary retroperitoneal, secondary retroperitoneal

A

Intraperitoneal - covered peritoneum, associated with mesentary

Primary retroperitoneal - develops and stays behind the peritoneum

Secondary retroperitoneal - originates within peritoneum but merges back

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3
Q

Name the two primary retroperitoneal organs

A

Kidneys

Adrenal glands

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4
Q

Name the secondary retroperitoneal organs

A

Retro kids party down to AC/DC records

Pancreas
Duodenum (descending and horizontal (2 and 3)
Ascending and descending colon
Rectum

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5
Q

The epiploic foramen connects ___ and ___ and is situated between ___ and ____

A

Greater and lesser sacs

Hepatogastric ligament and hepatoduodenal ligament (part of the lesser omentum)

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6
Q

The portal triad goes through what structure?

A

Epiploic foramen

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7
Q

What portion of the duodenum does the major duodenal papilla reside in?

A

Second part (descending)

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8
Q

What portion of the duodenum passes under SMA?

A

Horizontal (third part)

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9
Q

Where would you find brunner’s glands?

A

Duodenum

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10
Q

The right and left lobes of the liver are separated by….

A

The falciform ligament

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11
Q

Which is more soluble in blood, oxygen or carbon dioxide?

A

CO2

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12
Q

The rate of diffusion is affected by…

A

Solubility of the gas in the fluid
Surface area of the barrier across which diffusion occurs
Distance of diffusion (membrane thickness)
MW of gas
Temperature

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13
Q

Define tidal volume

A

This is the exchanged volume. Normal volume of air displaced between inhalation and exhalation

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14
Q

What is occurring when Va/Q approaches 0? What about when it is approaching infinity?

A

No air is reaching the alveolus (blood is shunted (leaves unoxygenated)

No blood is reaching the alveolus (physiological dead space increases)

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15
Q

What are the normal partial pressure values for oxygen and co2?

A
PO2 = 104
PCO2 = 40
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16
Q

True or false.. VA/Q is higher than normal in the superior portions of the lung (physiological dead space)

17
Q

Where in the lung does most shunting occur?

A

In the inferior portion of the lung. Less air is getting there than blood getting there (VA/Q=0.6)

18
Q

Blood that leaves the alveoli has a partial pressure of O2 of ___, but once it mixes with the shunted blood it becomes ____

A

104mmHg

95mmHg

19
Q

The percentage of blood that gives up its O2 is called the ____. At rest is about ___%, however, during exercise it can increase up to ____%

A

Utilization coefficient

25

85

20
Q

A shift to the right of an O2 disassociation curve means that…

What can cause this?

A

Hb gives up O2 more easily.

This can be caused by increase of temperature, increase of PCO2, increase of 2,3 DPG, and decrease of pH

21
Q

Define the bohr effect

A

The affinity of hemoglobin’s binding to O2 is inversely related to acidity and the concentration of CO2

22
Q

Hemoglobin + CO2 is called…

A

Carbaminohemoglobin

23
Q

Define the haldane effect

A

Deoxygenated blood has an increased ability to carry carbon dioxide. Thus we can infer that oxygenated blood carries less CO2

24
Q

True or false.. most blood cells mature in the periphery

25
A normal hematocrit is...
40-50%
26
What vitamins are necessary for RBC production?
B9, B12 and iron
27
What are three of the neutrophil effector mechanisms?
Phagocytosis Degranulation Net formation
28
True or false... neither platelets nor RBCs contain organelles
False.. RBCs do not contain organelles but platelets do. Neither contain a nucleus however
29
What are the three mechanisms for preventing blood loss?
Vascular constiction Platelet plug Coagulation (involves fibrin)
30
Coagulation is indicated by the production of ___
Thrombin prothrombin activator converts prothrombin to thrombin, this is the rate limiting step
31
In the coagulation pathway, thrombin will convert ___ to ___
Fibrinogen to fibrin monomers
32
Fibrin monomers for fibrin fibers through the use of ___. Fibrin fibers are then converted to a cross-linked fibrin fiber by ____
Calcium Thrombin -> activated fibrin stabilizing factor
33
Both the intrinsic and extrinsic pathway for producing the prothrombin activator require ___ and ___. What is the difference between these two pathways?
Calcium and vitamin K Intrinsic begins in the blood (tissue releases a 'help me' signal) Extrinsic begins at the site of tissue damage (exposure to collagen)
34
define holoenzyme
Complete catalitically active enzyme with all of the necesseary cofactors and coenzymes bound
35
True or false.. enzyme complentation to the substrate would decrease free energy demands
False.. it would increase the demands
36
Name four assumptions for Michaelis mention kinetics
Single substrate reaction Free diffusion of substrate Substrate concentration is below vmax Constant conditions
37
``` Describe the effects of Km and Vmax for the following... Competitive inhibiton Uncompetitive inhibition Noncompetitive inhibiton Mixed inhibition ```
Competitive: Km shifts right, Vmax unchanged Uncompetitive: Vmax lowered, slight left shift of Km Noncompetitive: Vmax lowered, no change in Km Mixed: Vmax lowered, Km shifts right