random Flashcards

1
Q

Causes of hyperandrogenism in women

A
PCOS
CAH
Ovarian/adrenal tumors
Hyperprolactinemia
Cushing Syndrome
Acromegaly
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2
Q

*** Added to pt with Metformin failure, SE of weight gain and hypoglycemia

A

Sulfonylureas

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3
Q

*** DM med with SE of weight gain, edema, CHF, bone fracture, bladder cancer

A

Pioglitazones

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4
Q

*** DM med that is weight neutral

A

DPP-IV inhibitors (sitagliptin)

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5
Q

DM med for someone who desire weight LOSS

A

GLP1receptor agonist

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6
Q

DPP-IV inhibitors (sitagliptin) is weight _____

A

neutral

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7
Q

Pt has inadequate mgmt of DM on Metformin and desires rx that will help him lose weight

A

GLP1 receptor agonist

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8
Q

These two non-insulin DM rx achieve the greatest A1C control

A

Metformin and Sulfonylurea

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9
Q

Two SE of insulin

A

Risk of hypoglycemia and weight gain

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10
Q

*** How can chronic GI disease affect Ca, Ph, Vit D and Parathyroid hormone

A

Chronic GI disease can lead to Vit D deficiency, which is needed for Ca and Ph absorption. With low Vit D, Ca and Ph become low and PTH increases.

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11
Q

Stimulation of TSH receptors by thyrotropin-receptor antibodies

A

Graves disease

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12
Q

Can estrogen in OCP, HRT, and pregnancy increase the level of T4-binding globulin resulting in ELEVATED total thyroid hormone levels but normal TSH?

A

Yes

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13
Q

*** Other name for a beta cell tumor

A

Insulinoma - pt with hypoglycemia and high c-peptide

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14
Q

F and ST in pt taking antithyroid medication

A

STOP rx - agranulocytosis

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15
Q

Infertility, decreased libido, impotence, gynecomastia in men

A

Prolactinoma

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16
Q

Autonomous production of thyroid hormones

A

Toxic adenoma

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17
Q

High titers of _____ antibodies are present in Hashimotos and confer increased risk of miscarriage

A

anti-TPO

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18
Q

*** ______ is an important cause of hypocalcemia, particularly in alcoholics

A

Hypomagnesemia

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19
Q

Pt comes in with recent virilization and you suspect a tumor. What labs?

A

Testosterone and DHEAS level
elevated T and normal DHEAS = ovarian
opposite = adrenal source

20
Q

Pt has a pheochromocytoma. What to give them before beta blockade?

A

alpha adrenergic block like phenoxybenzamine

21
Q

Flushing, lethargy, N/V, muscle weakness/cramps, watery diarrhea, low potassium, pancreatic tail tumor

22
Q

VIPoma + hyperparathyroidism

A

MEN syndromes

23
Q

Flushing, diarrhea, bronchospasm, tumor in small intestine

A

carcinoid tumor

24
Q

Causes of osteomalacia

A
VITAMIN D DEFICIENCY: 
malabsorption
bypass
celiac sprue
chronic liver or kidney disease
25
Decreased bone density with thinning of cortex, pseudofractures, impaired osteoid matrix mineralization, vitamin D deficiency
Osteomalacia
26
Old pt with T2DM found altered with BG > 1000.
Hyperosmolar hyperglycemic state - FIRST HYDRATE with NS, then IV INSULIN, supplement with POTASSIUM as needed
27
2nd step after Metformin, SE of weight gain and hypoglycemia
Sulfonylureas
28
DM rx with SE of weight gain, edema, CHF, bone fracture, bladder cancer
Pioglitazones
29
These two non-insulin DM medications acheive the greatest A1C control
Metformin and Sulfonylurea
30
Two SE of insulin
risk of hypoglycemia and weight gain
31
how can chronic GI disease affect Ca, Ph, Vit D and Parathyroid hormone
Chronic GI losses can lead to vitamin D deficiency, which is needed for Ca and Ph absorption. With low Vit D, Ca and Ph becomes low and as a result PTH increases.
32
stimulation of TSH receptors by thyrotropin-receptor antibodies
Graves disease
33
Can estrogen in OCP, HRT, and pregnancy increase the level of T4-binding globulin resulting in ELEVATED total thyroid hormone levels but normal TSH?
Yes
34
Tther name for a beta cell tumor
insulinoma - someone with hypoglycemia and high c-peptide
35
High titers of _____ antibodies are present in Hashimotos and have increased risk of miscarriage
anti-TPO
36
______ is an important cause of hypocalcemia, particularly in alcoholics
hypomagnesemia
37
Arthritis, reduced chest expansion and spinal mobility, tenderness at tendon sites, dactylitis, uveitis
AS
38
< 40 years old, back pain relieved with exercise, elevated ESR and CRP, HLA-B27
AS
39
What labs and imaging for AS?
XR of SI joint, labs with ESR, CRP, BLA-B27
40
AS complications
osteoporosis and vertebral fracture Aortic regurgitation Cauda equina
41
Young, oral apthous ulcers, genital ulcers, uveitis, erythema nodosus, thrombosis
Behcet disease
42
Will biopsy of vessels in Behcet disease show nonspecific vasculitis?
yes
43
Pathergy in Behcet disease
exaggerated skin response
44
Reactive arthritis (uveitis, arthritis, oral ulcerations) typically follows these two types of infections
GI or GU illness
45
Heberden nodes
OA - distal interphalangeal
46
Bouchard nodes
OA - proximal interphalangeal
47
*** > 50 yo with stiffnes in the neck, shoulder, and hip muscles
Polymylagia rheumatica