Renal Lec 7 Flashcards
(49 cards)
high [H+]= …. pH
low pH (acidic)
low [H+]= …. pH
high pH (basic/alkaline)
pH= (equation)
=log (1/[H+])= -log [H+]
pH for ECF is between
7.35 to 7.45
acidosis
arterial plasma pH < 7.35
alkalosis
arterial plasma pH > 7.45
why is balance of H+ important for body functions?
small changes in pH causes porteins to change shape
- enzymes: shape changes can alter their activity
- changes in neuronal activity
- coupled to K+ imbalances
- irregular cardiac beats
pH of ECF that lead to death
pH< 6.8
pH> 7.8
acid (def.)
release H+ in solution
Base (def.)
accepts H+ in solution
volatile acid (body)
carbon dioxide
volatile (def.)
exporative at normal temperatures
nonvolatile acids (body)
-organic and inorganic acids from other sources than CO2
nonvolatile acids (examples)
phosphoric acid
sulfuric acid
what produces sulfuric acid in body?
metabolism of sulfur-containing a.a (cysteine, methionine)
what produces hydrochloric acid in body?
metabolism of lysine, arginine and histidine
buffer (def.)
-any substance that binds to H+
buffer is composed of
weak acid and its conjugate base
buffers modify/adjust
-the change in pH following the addition of acids or bases
extracellular buffer system
CO2/HCO3-
intracellular buffer system
phosphate ions/proteins
example of intracellular buffer (blood)
Hemoglobin
H+ is buffered by both
extracellular/ intracellular fluid
organs responsible for balancing hydrogen ion concentration within narrow range
kidneys and lungs
