RENAL: vasculitis Flashcards Preview

Year 3 Medicine Block > RENAL: vasculitis > Flashcards

Flashcards in RENAL: vasculitis Deck (16)
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1
Q
A
2
Q

What type of kidney injury can vasculitis cause?

A

Acute

3
Q

How may vasculitis present?

A

Non-blanching rash
Knee/ankle pain
Inflammation of blood vessels in ENT
Neuro conditions

Pt with vague symptoms, haematuria and presence of ANCA

Dr Kenny’s workbook:
- raynauds
- msk - arthralgia, myalgia, prox muscle weakness
- cns - headaches, visual loss, stroke, seizures
- gi - abdo pain
- renal - haematuria
- limbs - neuropathy, digital ulcers, ischemia

4
Q

How is vasculitis treated?

A

Plasma exchange- take blood from pt and pass through filter which removes the antibodies driving the condition

Cyclosporin
Tacrolimus
Mycophenate motefil
Cylcophosphamide

Dr Kenny wrokbook:
- 1st line = corticosteroids
2nd line = cytotoxic meds, immunomodulatory drugs and biological agents.

5
Q

What antibody is implicated in vasculitis?

A

p-ANCA- anti-neurophil anti-cytoplasmic antibodies, they target neutrophil nucleus

c-ANCA- attaches to cytoplasm of nucleus

6
Q

What antibodies can cause vasculitis?

A

P-ANCA
C-ANCA

7
Q

What extra renal complications are related to AKPD?

A

Liver cysts
Berry aneurysms - check FHx of sudden death

8
Q

What are complications of AKPD?

A

Renal failure
Hypertension
Infection
Pain

9
Q

Why isn’t it useful doing genetic testing for AKPD?

A

High number of mutations - i.e. can not just test for ne mutation, have to test for 100s.

10
Q

What is inheritance pattern of AKPD?

A

Autosomal dominant

11
Q

Where is the mutation in Adult Polycystic Disease?

A

Polycystine gene, on chromosome 16 and chromosome 4

12
Q

How is Adult polycystic disease inherited?

A

Autosomal dominant

13
Q

How do you diagnose adult polycystic ovary syndrome?

A

Family history
Ultrasound- done over the age of 16 as cysts too small to be seen before then

14
Q

What are the features of adult polycystic kidney disease?

A

Bilateral cysts on the kidneys
HTN
Risk of berry aneurysms

15
Q

What are the complications of adult polycystic kidney disease?

A

Pain
Discomfort
Haematuria
Kidney failure

16
Q

What are the extra renal involvements of adult polycystic kidney disease?

A

Liver- doesn’t affect function too much, but pts may feel bloated and uncomfortable
Berry aneurysms

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