RHEUM: vasculitis Flashcards Preview

Year 3 Medicine Block > RHEUM: vasculitis > Flashcards

Flashcards in RHEUM: vasculitis Deck (11)
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1
Q
A
2
Q

What is vasculitis ? How is this big group of conditions divided?

A

Inflammation of blood vessels.

Divided based on whether they affect :
Small vessels
Medium vessels
Large vessels

3
Q

What are some examples of Small vessel vasculitis?

A

Microscopic polyangitis (MPA)

Granulomatosis with polyangitis (GPA): resp + kidneys+cANCA

Eosinophillic granulomatosis with polyangitis: assoicated with asthma + eosinophils +pANCA

IgA vasculitis

4
Q

What are some examples of medium vessel vasculitis?

A
Kawasaki disease (KD)
Polyarteritis nodsa (PAN)
5
Q

What are some examples of large vessel vasculitis?

A
Giant cell arteritis (GCA) 
Takayasu arteritis (TAK)
6
Q

what can cause Secondary vasculitis? (mimics vasculitis )

A

Drugs
Infection
malignancy
connective tissue disorder

7
Q

General Presentation of Vasculitis - features that most types share

A
Purpura (leaking blood vessels)
joint and muscle pain 
peripheral neuropathy 
ask about Raynaud's
Renal impairment h
GI disturbance (Abdo pain, PR bleeeding, diarrhoea)
Anterior uveitis and scleritis 
Hypertension
Systemic :
Fatigue
fever
weight loss
anorexia 
weight loss
8
Q

Investigations for Vasculitis

A

ALERT
Renal involvement - urine dipstick +/- microscopy - glomerulonephritis

Bloods:
FBC, U&Es, LFts, PV, CRP, ESR

serum antibodies :
ANCA - anti neutrophil cytoplasmic antibodies test for vasculitis - p-ANCA and c-ANCA
ANA
RF

p33 of rheum workbook has lots more detail of other tests

9
Q

Management of Vasculitis?

A

Depends on type - see pg 234 of Z2F for details.

General :
Rule out infection
stop offending drug e.g. secondary cause

1st line : Corticosteroids for target area
e.g. oral prednisolone/ IV hydrocortisone/ nasal/ inhaled

2nd line: Cyclophosphamide
Methotrexate
Azathioprine
rituximab

10
Q

______(1)_____ is a common cause of skin vasculitis due to medication

_____(2)______ can present with vasculitis like syndrome. ECHO will exclude

A

_____Hypersensitivity vasculitis_____ is a common cause of skin vasculitis due to medication

_____Atrial myxoma (tumour)______ can present with vasculitis like syndrome. ECHO will exclude

11
Q

What is the difference between GCA and trigeminal neuralgia?

A

GCA- chronic vasculitis of large and medium sized vessels in the head whereas TRIGEMINAL NEURALGIA- compression of trigeminal nerve

GCA- presents with headaches, stabbing facial pain and visual disturbances
TRIGEMINAL NEURALGIA- electric shock and knife pain unilaterally

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