Respiratory TB Flashcards Preview

Year 1: Respiratory > Respiratory TB > Flashcards

Flashcards in Respiratory TB Deck (14):
1

Which antibiotics should TB be treated with for the first two months?

First two months:
-rifampicin
-isoniazid
-pyrazinamide
-ethambutol

2

Which antibiotics should TB be treated with for months 2-6?

Months 2-6:
-rifampicin
-isoniazid

3

side effects of Rifampicin?

-colours urine and all body fluids orange
-is a potent inducer of cytochrome enzymes (so rapid breakdown of all steroid hormones including hormonal contraception, similar breakdown of opiate analgesics and other drugs)

4

side effects of ethambutol?

-can cause optic neuritis (inflammation of the optic nerve)

5

Single agent drug resistance in TB

commonly to isoniazid

6

multi-drug resistance in TB

resistance to rifampicin and isoniazid

7

Extensive drug resistance in TB

multi-drug resistance (rifampicin and isoniazid) and also quinolones and injectable (a type of contraception?)

8

Name 2 tests which test for previous exposure to TB

-interferon gamma release assay (a blood test)
-mantoux (tuberculin) test (a skin test)

9

Mantoux AKA tuberculin skin test

-requires 2 visits (patient has to return to see if there has been a delayed hypersensitivity reaction at site of injection)
-intradermal injection
-detects previous exposure to either TB or BCG - so can give false positives
-cannot distinguish between latent TB, cured TB, active TB, and BCG
-reaction may be diminished in IC patients

10

interferon gamma release assay (IGRA)

This assay looks for interferon gamma specific to antigens found only in mycobacteria tuberculosis. It doesn't react with BCG.
-only requires 1 visit
-high sensitivity

11

Anti-TNF therapy is used for patients with Crohn's, rheumatoid, psoriasis, ankylosing spondylitis. Why should you look for latent TB before prescribing anti-TNF therapy?

Anti-TNF therapy can cause re-activation of latent TB - usually within the first 12 weeks
If patient has latent TB: they should be given 6 months of isoniazid or 3 months of isoniazid and rifampicin also.

12

BCG vaccine

-it's an attenuated strain of mycobacterium bovis
-intradermal injection
-most effective in neonates of high risk families
-also provides some protection against leprosy

13

What other infection should all TB patients be tested for?

HIV
Also: all HIV cases should be offered a chest x-ray to check for TB

14

steroids and immunosuppressive drugs can reactivate latent TB. True/ False?

True