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Year 1: Respiratory > Treatment of COPD > Flashcards

Flashcards in Treatment of COPD Deck (6)
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1

clinical use of B2 agonists for COPD

used as ICS/ LABA combo or LAMA/ LABA combo or ICS/ LABA/ LAMA combo

2

clinical use of muscarinic antagonists

These block end-plate M3 receptors
Inhaled route only
used mostly in COPD to reduce exacerbations

3

Methylxanthines

these are non-selective PDE inhibitors, so promote bronchodilation. They also act as adenosine antagonists (when adenosine binds to mast cells: mast cells release histamine)

4

PDE4 inhibitors

these reduce exacerbations, and are additive to LABA/ LAMA
has adverse effects (nausea, diarrhoea, weight loss, headache)
rarely used
they are add ons to LABA/LAMA in frequent exacerbations instead of ICS

5

mucolytics

these reduce sputum viscosity and aid sputum expectoration
rarely used, and only used as add-on to other treatments

6

non-pharmacological managements of COPD

-smoking cessation
-immunisation (flu, pneumococcal)
physical activity
-venesection
-oxygen