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Flashcards in Rheumatology Deck (18)
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1

acute rheumatic fever - major criteria

SPACE:
subcutaneous nodules
pancarditis
arthritis (migratory)
chorea
erythema marginatum

2

acute rheumatic fever - minor criteria

fever, arthralgia, increased ESR/CRP, prolonged PR

3

diagnosis of acute rheumatic fever

2 major criteria OR 1 major and 2 minor + evidence of GAS infection

4

tx of rheumatic fever

penicillin x 10 days, prophy penicillin x 5 yrs or until age 21 (lifelong if carditis present)
ASA for arthritis, carditis

5

what HLA is associated with rheumatologic conditions?

HLA B27 (class I gene) is associated with spondylarthritis and enthesistis related JIA

6

definition of oligo JIA

max 4 involved joints in 6 months

7

what is associated with oligoarticular JIA?

uveitis (associated with positive ANA, cause of blindness!)

8

what is a secondary complication of systemic JIA

MAS

9

definition of systemic JIA

> 2 weeks of fever, arthritis AND one of:
- rash
- lymphadenopathy
- hepatosplenomegaly
- serositis

10

biologics used in systemic JIA

anti-IL1 (anakinra), anti-IL6 (tocilizumab)

11

gene associated with FMF

MEFV, production of pyrin (regulates neutrophil-mediated inflammation)

12

features of FMF

brief, recurrent episodes (1-3 days) of fever, assoc with painful polyserositis (peritonitis, pleuritis, arthritis)

13

what is the risk of untreated FMF

amyloidosis in 60%, renal failure

14

PFAPA

regularly recurring fevers with apthous stomatitis, cervical lymphadenopathy, pharyngitis (in the absence of URTI sxs)

15

what is the most common vital organ involved in SLE?

kidney (glomerulonephritis)

16

most sensitive test for lupus

ANA

17

HSP

palpable purpura, arthritis, abdo pain, IgA nephropathy

18

tx kawasaki

IVIG 2 g/kg