Renal Tubular Acidosis Flashcards Preview

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Flashcards in Renal Tubular Acidosis Deck (14)
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1

Type 1 Distal RTA

Impaired ability to secrete acid (acidify urine), results in:

- alkaline urine (< 5.5)
- metabolic acidosis
- hyperchloremia (loss of HCO3)
- hypokalemia (unable to secrete H+)
- hypercalciuria

2

Which type of RTA results in an ability to acidify urine?

Type 1 distal RTA

3

What is the metabolic abnormality in distal type 1 RTA?

hyperchloremic metabolic acidosis
- hypokalemia
- hypercalciuria

4

What is Fanconi syndrome?

global proximal tubule dysfunction

5

In Fanconi syndrome, what is lost in the urine?

Glucose
Amino acids
LMW protein
Phosphate
Bicarbonate

6

MSK manifestation of Fanconi syndrome

FTT
short stature
hypophosphatemic rickets

7

Genetic causes of Fanconi syndrome

Cystinosis
Lowe syndrome
Tyrosinemia
Galactosemia
WIlson's disease
Dent's disease

8

Acquired causes of fanconi syndrome

Medications (Cisplatin, ifosfamide, valproate)

9

Clinical features of Fanconi syndrome

Rickets
FTT
short stature
dental enamel defects
intellectual impairment
ocular anomalies - glaucoma, cataracts

10

What is cystinosis?

Accumulation of cystine crystals in major organs (kidney, liver, eye, brain)

11

What type of RTA do people with cystinosis get?

Type II, proximal (Fanconi syndrome)

12

What is type 4 RTA?

Hypoaldosteronism (or pseudohypoaldosteronism)

13

What can cause pseudohypoaldosteronism?

obstructive uropathy, UTI / pyelo

14

What are the important electrolyte abnormalities in pseudohypoaldosteronism?

Hyperkalemia
Hyponatremia