Flashcards in Renal Tubular Acidosis Deck (14)
Type 1 Distal RTA
Impaired ability to secrete acid (acidify urine), results in:
- alkaline urine (< 5.5)
- metabolic acidosis
- hyperchloremia (loss of HCO3)
- hypokalemia (unable to secrete H+)
Which type of RTA results in an ability to acidify urine?
Type 1 distal RTA
What is the metabolic abnormality in distal type 1 RTA?
hyperchloremic metabolic acidosis
What is Fanconi syndrome?
global proximal tubule dysfunction
In Fanconi syndrome, what is lost in the urine?
MSK manifestation of Fanconi syndrome
Genetic causes of Fanconi syndrome
Acquired causes of fanconi syndrome
Medications (Cisplatin, ifosfamide, valproate)
Clinical features of Fanconi syndrome
dental enamel defects
ocular anomalies - glaucoma, cataracts
What is cystinosis?
Accumulation of cystine crystals in major organs (kidney, liver, eye, brain)
What type of RTA do people with cystinosis get?
Type II, proximal (Fanconi syndrome)
What is type 4 RTA?
Hypoaldosteronism (or pseudohypoaldosteronism)
What can cause pseudohypoaldosteronism?
obstructive uropathy, UTI / pyelo