Flashcards in Rhinitis and Rhinorrhoea Deck (12):
What does rhinitis cause?
Acute or chronic inflammation of the nasal mucosa
In allergic rhinitis, inhalation of the allergen increases what?
Specific IgE levels
What does IgE bind to?
Receptors on mast cells and basophils
What does re-exposure to the antigen cause?
Mast cell and basophil degranulation
What does degranulation of mast cells and basophils cause release of?
Histamine, CysLT, tryptase, prostaglandins
What is involved in the delayed response which causes congestion and obstruction?
Lymphocytes and eosinophils
What is non-allergic rhinitis?
Rhinitis not involving IgE
What do rhinitis and rhinorrhoea cause in increase of?
Mucosal blood flow, blood vessel permeability or both
How do you treat the anti-inflammatory aspect?
How do you block the mediators?
Histamine, CysLT1 receptor antagonists
How do you target nasal blood flow?