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Flashcards in RTI IX Deck (35):
1

Chlamydophila psittaci is a (G+ve/G-ve) and obligate _____ and causes ______

Chlamydophila psittaci is a G-ve and obligate intracellular and causes Ornithosis (Psittacosis, Parrot fever) 

2

Chlamydophila psittaci are round with narrow _____

Chlamydophila psittaci  are round with narrow periplasmic space

3

Chlamydophila psittaci has no _____ in the cell wall and instead contains a _____ with weak endotoxicity

Chlamydophila psittaci  has no peptidoglycan in the cell wall and instead contains a lipopolysaccharide (LPS) with weak endotoxicity

4

____ is a major cell wall component and unique to each Chlamydophila species

Major Outer Membrane Protein (MOMP) is a major cell wall component and unique to each Chlamydophila species

5

Chlamydophila psittaci

small infectious EBs attach to _____, followed by _____ 

small infectious EBs attach to microvilli, followed by active penetration in the cell

6

Chlamydophila psittaci

intact _____ inhibits fusion to the ___ thus, not killing Chlamydia

intact EB outer membrane inhibits fusion to the lysosomes thus, not killing Chlamydia

7

Chlamydophila psittaci

6-8 hours after penetration, ____ reorganize to become _____

18-24 hrs later, the ____ divide to become ____

6-8 hours after penetration, EBs reorganize to become large metabolically active RBs

18-24 hrs later, the RBs divide to become smaller EBs again, rupturing the host cell

8

Chlamydophila psittaci is transmitted to humans through _____

Chlamydophila psittaci is transmitted to humans through inhalation of excreta, urine or resp. droplets of birds

9

Chlamydophila psittaci spreads to the ____ producing necrosis

Chlamydophila psittaci  spreads to the RES of liver and kidneys producing necrosis

10

Chlamydophila psittaci is seeded in the lung through ____ causing lymphocytic inflammation in the _____

Chlamydophila psittaci is seeded in the lung through blood causing lymphocytic inflammation in the alveoli

11

Chlamydophila psittaci produces edema, thickening of the ___, infiltration of ____, necrosis and occasional hemorrhages

Chlamydophila psittaci  produces edema, thickening of the alveolar walls, infiltration of macrophages, necrosis and occasional hemorrhages

12

name the populations at highest risk of Chlamydophila psittaci

  • high risk:
    • vets
    • zookeepers
    • pet shop owners
    • employees of poultry-processing plants

13

describe clinical features of Chlamydophila psittaci

14

diagnosis of Chlamydophila psittaci is by _____

diagnosis of Chlamydophila psittaci is by serology

15

describe the biology of Hantavirus

  • family = bunyavirus 
    • negative sense ssRNA virus
  • RNA virus, spherical, lipid envelope with 2 major glycoproteins

16

______ is the commonest cause of HPS (Hantavirus Pulmonary Syndrome) and is carried by _____

Sin nombre virus is the commonest cause of HPS (Hantavirus Pulmonary Syndrome) and is carried by the deer mouse

17

name settings where exposure to rodents (thus leading to HPS) is common

  • peridomestic settings:
    • barns
    • outbuildings
    • sheds
    • camping

18

hantavirus is mainly transmitted to humans when _____

hantavirus is mainly transmitted to humans when  they breathe in air contaminated with the virus - airborne transmission (most common)

19

describe the 3 clinical phases seen in HPS

20

in HPS, there is a generalized increase in _____ that results from ____ damage

in HPS, there is a generalized increase in capillary permeability that results from endothelial damage

21

injury in HPS is a consequence of _____ 

injury in HPS is a consequence of the host's immunological response to viral antigens that have penetrated the endothelium

22

describe the diagnosis and treatment of HPS

23

Meliodosis (Whitemore's disease) is an infection caused by _____

where is this disease endemic in?

Meliodosis (Whitemore's disease) is an infection caused by Burkholderia pseudomallei

endemic regions = South Asia, SE Asia including China, northern Australia

24

Burkholderia pseudomallei is (G+ve/G-ve), rod-shaped, motile, aerobic

Burkholderia pseudomallei is G-ve, rod-shaped, motile, aerobic

25

Burkholderia pseudomallei is G-ve, rod-shaped, (motile/non-motile), aerobic

Burkholderia pseudomallei is G-ve, rod-shaped, motile, aerobic

26

the predominant mode of transmission of Burkholderia pseduomallei is through _____

the predominant mode of transmission of Burkholderia pseduomallei  is through broken skin (percutaneous inoculation during exposure to wet soils or contaminated water)

27

list risk factors for Meliodosis 

28

adults with Meliodosis primarily present with ____

while

children with Meliodosis primarily present with _____

adults with Meliodosis primarily present with pneumonia

while

children with Meliodosis primarily present with cutaneous infxns

29

describe the lab diagnosis of Meliodosis

30

Meliodosis is grown on ____ agar and has a _____ morphology

Meliodosis  is grown on Ashdown's agar and has a cauliflower-head morphology

31

describe what is seen on microscopy of Meliodosis

G-ve bacilli, bipolar staining 

32

Coxiella burnietti is an obligate _____ and ____ are important reservoirs

Coxiella burnetti is an obligate intracellular bacteria (G-ve)  and cattle, sheep, goats are important reservoirs

33

describe the 3 main acute clinical presentations of Q fever

  • self-limiting flu-like illness
  • pneumonia (predominant in N. America)
  • hepatitis (predominant in Europe)

34

describe the 2 phases of Coxiella burnetti

  • phase I
    • highly infectious with intact LPS
  • phase II
    • not infectious, with truncated LPS

35

describe chronic Q fever and those at risk for it

sometimes present years after primary infection: culture negative endocarditis 

  • risk group:
    • pre-existing heart defects
    • pregnancy
    • immunocompromised