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Flashcards in Skin II Deck (36):
1

most Staphylococci are ____-resistant because they secrete ____ 

most Staphylococci are penicillin-resistant because they secrete penicillinase (hydrolyze penicillin)

2

multidrug resistance of MRSA is mediated by an acquired chromosomal DNA segment, ____ which encodes a new ____

multidrug resistance is mediated by an acquired chromosomal DNA segment, mecA which encodes a new penicillin-binding protein 2A

3

list the risk factors for MRSA in the community

4

list the risk factors for MRSA in healthcare

5

describe CA-MRSA vs. HA-MRSA

6

___ is an important toxin used to differentiate between CA-MRSA and HA-MRSA

Pantin-Valentine leucocidin (PVL)

7

list the syndromes that affect the epidermis

  • impetigo
  • folliculitis

8

list the syndromes that affect the dermis

  • ecthyma
  • erysipelas
  • furunculosis
  • carbunculosis

9

list the syndromes that affect the hypodermis (sliding layer)

  • necrotizing fasciitis 

10

list the syndromes that affect the muscle

  • myonecrosis

11

describe impetigo

  • 3rd most common skin disease among children
  • risk factors:
    • have an injury (cut, fracture, burn, scrape)
    • contagious
  • isolates of CA and HA-acquired MRSA in lesions of impetigo remains low 

12

describe nonbullous impetigo

  • the teichoic acid adhesions (fibronectin-binding proteins (FnBPs)) require the epithelial cell receptor component, fibronectin, for colonization
  • these fibronectin receptors are unavailable on intact skin

13

in nonbullous impetigo, the ____ require the epithelial cell receptor component, ____, for colonization which is normally unavailable on ____ skin

in nonbullous impetigo, the teichoic acid adhesions (FnBPs) require the epithelial cell receptor component, fibronectin, for colonization which is normally unavailable on intact skin

14

describe bullous impetigo

  • group II S. aureus
  • cause: exfoliating toxin, a protease that degrades desmoglein-1, resulting in loss of adhesion of the superficial epidermis 
  • unlike nonbullous impetigo, the lesions of bullous impetigo occur on intact skin

15

bullous impetigo is caused by ____

bullous impetigo is caused by group II S. aureus

16

bullous impetigo is caused by ___ which is a protease that degrades ___ resulting in a loss of adhesion of ____

bullous impetigo is caused by exfoliating toxin which is a protease that degrades desmoglein-1 resulting in a loss of adhesion of the superficial epidermis

17

unlike nonbullous impetigo, the lesions of bullous impetigo occur on ____

unlike nonbullous impetigo, the lesions of bullous impetigo occur on intact skin

18

describe the treatment/prevention of impetigo

19

describe the condition in the image

20

describe cellulitis and erysipelas and the most common pathogens

21

list other causes of cellulits, erysipelas

"don't have to know this"

22

describe the clinical presentation of erysipelas 

23

erysipelas has ___ borders and involves the upper ___ and superficial ____

erysipelas has well-defined borders and involves the upper dermis and superficial lymphatics

24

cellulitis has ____ borders that expands ____ and is often accompanied by ____

cellulitis has ill-defined borders that expands rapidly and is often accompanied by lymphangitis

25

erysipelas has a predilection for ___ and ___

while

cellulitis is most common in ___ and ____

erysipelas has a predilection for young children and the elderly

while

cellulitis is most common in middle-aged and elderly people

26

cellulitis and erysipelas are not ____ since ____

cellulitis and erysipelas are not considered contagious since the bacteria has to enter the body through broken skin

27

folliculitis is a superficial infection of ____

folliculitis is a superficial infection of the hair follicles 

28

list the pathogens that cause folliculitis

  • S. aureus = most common
  • P. aeruginosa = associated with the use of un-chlorinated hot tubs

29

describe skin abscesses (furuncles and carbuncles) and the most common cause

  • a skin abscess is an infection of the dermis and deeper layers of skin that contains purulent material
  • S. aureus is the most common cause

30

when a single follicle is infected and tracks down into the dermis, it is termed a ____

when multiple infected hair follicles coalesce, it is a ____

when a single follicle is infected and tracks down into the dermis, it is termed a furuncle

when multiple infected hair follicles coalesce, it is a carbuncle

31

the greatest risk factor for furuncles and carbuncles is ____

the greatest risk factor for furuncles and carbuncles is intravenous drug use

32

describe the clinical presentation of furuncles and carbuncles

33

the microorganism responsible for inflammatory acne is ____

the microorganism responsible for inflammatory acne is Propionibacterium acnes

34

the microorganism responsible for inflammatory acne, ____, feeds on ___ and ___ in plugged pores and follicles

the microorganism responsible for inflammatory acne, Propionibacterium acnes, feeds on sebum and keratin in plugged pores and follicles

35

describe pilonidal abscesses

they are usually associated with _____

they are usually associated with anaerobic bacteria

36

acute paronychia is caused by ____

while

chronic paronychia is caused by _____

acute paronychia is caused by staphylococci

while

chronic paronychia is caused by fungal infection (Candida spp.)