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Flashcards in Skin I Deck (16):
1

describe the natural defenses of the skin

  • keratin
  • antimicrobial peptides (AMPs): host defense
  • skin sloughing
  • sebum:
    • low pH
    • lipid (sphingoid bases)
  • sweat:
    • low pH
    • high salt
    • lysozyme (digests peptidoglycan)

2

sebum has a ___ pH and contains ___

sebum has a low pH and contains lipid (sphingoid bases)

3

sweat has a ___ pH, high ___ and contains ____ which helps digest ____

sweat has a low pH, high salt and contains lysozyme which helps digest peptidoglycans

4

____ spp. predominate in sebaceous areas

Propionibacterium spp. predominate in sebaceous areas

5

____ spp. predominate in moist areas

Corynebacterium and Staphylococcus spp. predominate in moist areas

6

dry areas of the body exhibit ____

dry areas of the body exhibit  the greatest amount of diversity and lower load (less selective force)

7

susceptibility genes such as ____ can lead to higher rates of ____

susceptibility genes such as filaggrin can lead to higher rates of atopic dermatitis

8

contrast primary vs. secondary skin infections

  • primary: skin infections caused by a single pathogen and affect normal skin
    • ex: SA, B-hemolytic strep.
  • secondary: occur in skin that is already diseased
    • overgrown resident flora
    • toe web infection (athlete's foot) regarded as a fungal infection is now believed to be caused first by dermatophytes, which cause skin damage that allows bacterial overgrowth of certain coryneform bacteria and Brevibacterium

9

Pseudomonas aeruginosa is the leading cause of ____ and is known for causing infections in patients with ____ (3 things)

Pseudomonas aeruginosa  is the leading cause of nosocomial G-ve associated infections and is known for causing infections in patients with extensive burns, patients treated with cytotoxic drugs and patients with CF 

10

a major virulent factors of Pseudomonas is its capacity to ____ and one of its most worrying characteristics is its ____

a major virulent factors of Pseudomonas is its capacity to form biofilms and one of its most worrying characteristics is its low antibiotic susceptibility

11

Pseudomonas has an ____ mode of metabolism, which means that ___ is NOT employed

Pseudomonas has an obligate resp. mode of metabolism, which means that fermentation is NOT employed

  • does NOT ferment lactose, which sets them apart from the Enterobacteriaceae

12

____ test is a rapid test which is used for the presumptive identification of group A B-hemolytic streptococci and enterococci

PYR (pyrrolidonyl arylamidase) test is a rapid test which is used for the presumptive identification of group A B-hemolytic streptococci and enterococci

13

PYR (pyrrolidonyl arylamidase) test is a rapid test which is used for the presumptive identification of _____

PYR (pyrrolidonyl arylamidase) test is a rapid test which is used for the presumptive identification of group A B-hemolytic streptococci and enterococci

14

describe the function of protein A

15

the target of exfoliative toxin found in S. aureus is ____

the target of exfoliative toxin found in S. aureus is desmoglein-1

16

it is important to differentiate Strep. from Staph. because Staph. is ____

which 2 lab tests can differentiate?

it is important to differentiate Strep. from Staph. because Staph. is  resistant to penicillin G

Gram staining and catalase test can differentiate